抗体

BCL2(磷酸化Ser70)抗体

MBS851035

0.1毫克

215美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

BCL2(磷酸化Ser70)抗体

BCL2

Apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; BCL2

apoptosis regulator Bcl-2 alpha isoform; Apoptosis regulator Bcl-2; apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50; B-cell CLL/lymphoma 2

BCL2

BCL2; BCL2; Bcl-2; PPP1R50

BCL2_HUMAN

兔

小鼠, 大鼠

239

BCL2 (Phospho-Ser70) antibody detects endogenous levels of BCL2 only when phosphorylated at serine 70.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20 degree C for 1 year

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

WB: 1:500~1:1000, ELISA: 1:40000

Reactivity Note: Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human BCL2 around the phosphorylation site of serine 70 (R-T-SP-P-L). All Sites: Mouse: Ser70; Rat: Ser70. Pathway: Phospho-specific

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Tsujimoto Y., Proc. Natl. Acad. Sci. U.S.A. 83:5214-5218(1986). Eguchi Y., Nucleic Acids Res. 20:4187-4192(1992). Cleary M.L., Cell 47:19-28(1986). ----------------------------------------------------------------------------

72198189

NP_000624.2

NM_000633.2

P10415

22,337 Da

ATF-2 Transcription Factor Network Pathway (138006); Activation Of BAD And Translocation To Mitochondria Pathway (105659); Activation Of BH3-only Proteins Pathway (105658); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198797); Apoptosis Pathway (83060)

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]

Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions. Protein type: Oncoprotein; Membrane protein, integral; Apoptosis; Autophagy. Chromosomal Location of Human Ortholog: 18q21.3. Cellular Component: pore complex; mitochondrial outer membrane; endoplasmic reticulum membrane; nuclear membrane; mitochondrion; membrane; endoplasmic reticulum; cytoplasm; cytosol; nucleus; myelin sheath. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; sequence-specific DNA binding; protein heterodimerization activity; channel activity; ubiquitin protein ligase binding; BH3 domain binding; channel inhibitor activity; transcription factor binding. Biological Process: focal adhesion formation; response to nicotine; positive regulation of catalytic activity; developmental growth; renal system process; pigment granule organization and biogenesis; protein polyubiquitination; response to toxin; response to glucocorticoid stimulus; T cell differentiation in the thymus; ear development; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; female pregnancy; glomerulus development; negative regulation of mitochondrial depolarization; post-embryonic development; cochlear nucleus development; cellular response to glucose starvation; negative regulation of myeloid cell apoptosis; B cell receptor signaling pathway; regulation of mitochondrial membrane potential; negative regulation of ossification; positive regulation of B cell proliferation; regulation of transmembrane transporter activity; T cell homeostasis; negative regulation of neuron apoptosis; cell growth; defense response to virus; spleen development; response to drug; positive regulation of neuron maturation; release of cytochrome c from mitochondria; axon regeneration; regulation of protein homodimerization activity; actin filament organization; cell aging; digestive tract morphogenesis; regulation of calcium ion transport; positive regulation of cell growth; organ growth; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; negative regulation of osteoblast proliferation; gland morphogenesis; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; negative regulation of apoptosis; B cell proliferation; negative regulation of autophagy; regulation of protein heterodimerization activity; behavioral fear response; melanin metabolic process; apoptosis; regulation of cell-matrix adhesion; negative regulation of retinal cell programmed cell death; regulation of protein stability; positive regulation of smooth muscle cell migration; protein amino acid dephosphorylation; response to radiation; positive regulation of skeletal muscle fiber development; B cell homeostasis; ovarian follicle development; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; transmembrane transport; response to iron ion; negative regulation of cellular pH reduction; negative regulation of cell migration; regulation of viral genome replication; mesenchymal cell development; ossification; CD8-positive, alpha-beta T cell lineage commitment; hair follicle morphogenesis; thymus development; B cell lineage commitment; male gonad development; peptidyl-threonine phosphorylation; positive regulation of peptidyl-serine phosphorylation; humoral immune response; response to UV-B; endoplasmic reticulum calcium ion homeostasis; peptidyl-serine phosphorylation; neuron apoptosis; response to hydrogen peroxide; axonogenesis; ureteric bud branching; homeostasis of number of cells within a tissue; response to cytokine stimulus; innate immune response; negative regulation of cell growth; induction of apoptosis by oxidative stress; response to DNA damage stimulus

0.1毫克

215美元