抗体

LAMA3抗体

MBS851791

0.1毫克

215美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法

抗体

LAMA3抗体

LAMA3

Laminin subunit alpha-3; Epiligrin 170 kDa subunit; E170; Nicein subunit alpha; LAMA3; LAMNA

laminin subunit alpha-3 isoform 2; Laminin subunit alpha-3; laminin subunit alpha-3; BM600 150kD subunit; nicein 150kD subunit; nicein subunit alpha; kalinin 165kD subunit; kalinin subunit alpha; epiligrin subunit alpha; laminin-5 alpha 3 chain; laminin-5 subunit alpha; laminin-6 subunit alpha; laminin-7 subunit alpha; epiligrin 170 kda subunit; epiligrin alpha 3 subunit; laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin); laminin, alpha 3; Epiligrin 170 kDa subunit; E170; Epiligrin subunit alpha; Kalinin subunit alpha; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; Nicein subunit alpha

LAMA3

LAMA3;LAMA3;E170;LOCS;BM600;LAMNA;lama3a;LAMNA;E170

LAMA3_HUMAN

兔

人类, 小鼠, 大鼠

1724

LAMA3抗体检测内生水平总数LAMA3蛋白

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20 degree C for 1 year

免疫组化(免疫组化), 免疫荧光(IF), 酶联免疫吸附测定(EIA)

IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:1000

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human LAMA3. Pathway: Adhesion

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Ryan M.C., J. Biol. Chem. 269:22779-22787(1994). Vidal F., Genomics 30:273-280(1995). McLean W.H.I., Hum. Mol. Genet. 12:2395-2409(2003). ------------------------------------------------------------------------------------------------------------------------------------------

38045908

NP_000218.2

NM_000227.3

Q16787

184,054 Da

Alpha6-Beta4 Integrin Signaling Pathway (198807); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Anchoring Fibril Formation Pathway (730307); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Collagen Formation Pathway (645288); Degradation Of The Extracellular Matrix Pathway (576263); ECM Proteoglycans Pathway (833812)

Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

LAMA3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMA3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMA3 are the cause of laryngoonychocutaneous syndrome (LOCS). LOCS is an autosomal recessive epithelial disorder confined to the Punjabi Muslim population. The condition is characterized by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conjunctiva and larynx. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 18q11.2. Cellular Component: laminin-5 complex; laminin-1 complex; extracellular region; basement membrane. Molecular Function: structural molecule activity; receptor binding. Biological Process: regulation of cell adhesion; extracellular matrix disassembly; epidermis development; hemidesmosome assembly; extracellular matrix organization and biogenesis; regulation of embryonic development; cell adhesion; regulation of cell migration. Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Laryngoonychocutaneous Syndrome; Epidermolysis Bullosa, Junctional, Herlitz Type

0.1毫克

215美元