抗体

雌激素受体β(磷酸化Ser105)多克隆抗体

MBS8520327

0.1毫克

280美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 酶免疫法

抗体

雌激素受体β(磷酸化Ser105)多克隆抗体

[雌激素受体β]

[ERS2; ESTRB; NR3A2; Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2]

[estrogen receptor beta isoform 2; Estrogen receptor beta; estrogen receptor beta; estrogen receptor 2; Nuclear receptor subfamily 3 group A member 2]

[雌激素受体β]

[ESR2; ESR2; Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA; ESTRB; NR3A2; ER-beta]

多克隆

兔

人类, 小鼠, 大鼠

495

Phospho-ERb(S105)Polyclonal Antibody detects endogenous level of ERb protein only when phosphorylated at S105.

The antibody was affinity purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠

1毫克/毫升

Store at -20°C/1 year.

免疫印迹(免疫印迹), 免疫荧光(IF), 酶联免疫吸附测定(EIA)

免疫印迹(免疫印迹)1/500-1/2000。 免疫荧光(IF)1/200-1/1000。 酶联免疫吸附测定(EIA)1/5000。 尚未在其他应用中测试

Western Blot analysis of HepG2 cells using Phospho-ERb (S105) Polyclonal antibody.

Immunogen: Synthesized peptide derived from human ERbeta around the phosphorylation site of S105

94538325

NP_001035365.1

NM_001040275.1

Q92731

59.216

Estrogen Signaling Pathway (799177); Estrogen Signaling Pathway (799197); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Integrated Pancreatic Cancer Pathway (711360); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848); Ovarian Infertility Genes Pathway (198801); Plasma Membrane Estrogen Receptor Signaling Pathway (138009); Prolactin Signaling Pathway (814182)

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

0.1毫克

280美元