抗体

血小板衍生的生长因子受体b(磷酸化Tyr771)抗体

MBS852119

0.1毫克

215美元

多克隆

兔

未共轭

人类, 大鼠

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

血小板衍生的生长因子受体b(磷酸化Tyr771)抗体

血小板衍生的生长因子受体b

Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; JTK12; PDGF-R-beta; PDGFR; PDGFR1; PDGFRB; PGFRB; platelet-derived growth factor receptor; beta polypeptide

platelet-derived growth factor receptor beta; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta; PDGFR-beta; PDGF-R-beta; CD140 antigen-like family member B; platelet-derived growth factor receptor 1; beta-type platelet-derived growth factor receptor; platelet-derived growth factor receptor, beta polypeptide; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD_antigen: CD140b

血小板衍生的生长因子受体b

血小板衍生的生长因子受体b;血小板衍生的生长因子受体b;IMF1;IBGC4;JTK12;PDGFR;CD140B;血小板衍生的生长因子受体1;PDGFR-1;PDGFR;血小板衍生的生长因子受体1;PDGF-R;PDGFR乙;PDGFR-1

PGFRB_HUMAN

兔

人类, 大鼠

1106

PDGFRb (Phospho-Tyr771) Antibody detects endogenous levels of PDGFRB only when phosphorylated at tyrosine 771.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20 degree C for 1 year

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

WB: 1:500~1:3000, ELISA: 1:1000

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human PDGFRB around the phosphorylation site of tyrosine 771. All Sites: Human: Tyr771; Rat: Tyr770. Pathway: Phospho-specific

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Schmutz J., Nature 431:268-274(2004). Gronwald R.G.K., Proc. Natl. Acad. Sci. U.S.A. 85:3435-3439(1988). Gronwald R.G.K., Proc. Natl. Acad. Sci. U.S.A. 85:3435-3439(1988).

4505683

NP_002600.1

NM_002609.3

P09619

37,412 Da

Adaptive Immune System Pathway (366160); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385)

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]

PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent. Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; Oncoprotein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; PDGFR family. Chromosomal Location of Human Ortholog: 5q33.1. Cellular Component: lysosomal lumen; focal adhesion; cell surface; membrane; apical plasma membrane; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane; nucleus; intrinsic to plasma membrane. Molecular Function: protein binding; platelet activating factor receptor activity; platelet-derived growth factor binding; platelet-derived growth factor beta-receptor activity; protein-tyrosine kinase activity; platelet-derived growth factor receptor binding; phosphoinositide 3-kinase binding; platelet-derived growth factor receptor activity; protein kinase binding; ATP binding; receptor binding. Biological Process: positive regulation of phosphoprotein phosphatase activity; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; wound healing; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; response to toxin; positive regulation of collagen biosynthetic process; platelet-derived growth factor receptor signaling pathway; cardiac myofibril assembly; signal transduction; positive regulation of smooth muscle cell migration; response to estradiol stimulus; positive regulation of MAP kinase activity; smooth muscle development; positive regulation of cell proliferation; tissue homeostasis; phosphatidylinositol metabolic process; regulation of peptidyl-tyrosine phosphorylation; inner ear development; epidermal growth factor receptor signaling pathway; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; response to retinoic acid; positive regulation of mitosis; adrenal gland development; in utero embryonic development; positive regulation of chemotaxis; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; glycosaminoglycan biosynthetic process; G-protein coupled receptor protein signaling pathway; response to hyperoxia; response to hydrogen peroxide; skeletal morphogenesis; regulation of actin cytoskeleton organization and biogenesis; innate immune response; positive regulation of cell migration; negative regulation of apoptosis. Disease: Myeloproliferative Disorder, Chronic, With Eosinophilia; Myofibromatosis, Infantile, 1; Basal Ganglia Calcification, Idiopathic, 1; Basal Ganglia Calcification, Idiopathic, 4

0.1毫克

215美元