产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
组蛋白H3(Ab-3)抗体
目录 :
MBS852662
规格 :
0.1毫克
价格 :
215美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS852662
产品类型 :
抗体
产品全称 :
组蛋白H3(Ab-3)抗体
产品简称 :
组蛋白H3
产品名称同义词 :
H3/a;H3/c;H3/d;H3/f;H3/h;H3/i;H3/j;H3/k;H3/l;H31;HIST1H3A;组蛋白H3.1
其他名称 :
histone H3.1; Histone H3.1; histone H3.1; histone H3/a; histone 1, H3a; H3 histone family, member A; histone cluster 1, H3a; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l
其他基因名称 :
HIST1H3A;HIST1H3A;H3/A;H3FA;H3FA
UniProt数据库进入名 :
H31_HUMAN
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
136
特异性 :
组蛋白H3(Ab-3)抗体检测内生水平总数组蛋白H3蛋白
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
形式 :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
储存稳定性 :
Store at -20 degree C for 1 year
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 酶联免疫吸附测定(EIA)
应用笔记 :
WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:5000
其它信息1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
其他信息2 :
Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Histone H3 around the phosphorylation site of threonine 3 (A-R-TP-K-Q). Pathway: Transcription
产品种类 :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
产品引用 :
Zhong R., Nucleic Acids Res. 11:7409-7425(1983). Marashi F., Biochem. Cell Biol. 64:277-289(1986). Albig W., Genomics 10:940-948(1991).
NCBI GI登录号 :
4504281
NCBI登录号 :
NP_003520.1
NCBI基因登录号 :
NM_003529.2
UniProt数据库登录号 :
P68431
NCBI分子量 :
15,404 Da
NCBI信号通路 :
Alcoholism Pathway (585563); Alcoholism Pathway (587116); Amyloids Pathway (366238); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Chromatin Modifying Enzymes Pathway (941403); Chromatin Organization Pathway (941402); Condensation Of Prophase Chromosomes Pathway (941401)
NCBI总结 :
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
H3: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p22.2. Cellular Component: nucleoplasm; nuclear chromosome; protein complex; membrane; extracellular region; nucleosome; nucleus. Molecular Function: protein binding; DNA binding; histone binding; protein heterodimerization activity. Biological Process: chromatin silencing at rDNA; nucleosome assembly; establishment and/or maintenance of chromatin architecture; negative regulation of gene expression, epigenetic; protein heterotetramerization; gene expression; blood coagulation; DNA methylation on cytosine; regulation of gene expression, epigenetic; DNA replication-dependent nucleosome assembly
尺寸1 :
0.1毫克
价格1 :
215美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。