胶原IV甲2抗体 | MyBioSource MBS853194 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

胶原IV甲2抗体

MBS853194

规格 :

0.1毫克

价格 :

215美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类, 小鼠

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法

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产品信息

目录号 :

MBS853194

产品类型 :

抗体

产品全称 :

胶原IV甲2抗体

产品简称 :

胶原IV甲2

产品名称同义词 :

Collagen IV a2 Antibody; CO4A2; Collagen alpha-2(IV) chain; alpha 2 type IV collagen; canstatin; collagen type IV alpha 2

其他名称 :

collagen alpha-2(IV) chain preproprotein; Collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; canstatin; collagen, type IV, alpha 2

其他基因名称 :

COL4A2;COL4A2;ICH;POREN2

UniProt数据库进入名 :

CO4A2_HUMAN

宿主 :

兔

反应物种 :

人类, 小鼠

序列长度 :

1712

特异性 :

胶原IV alpha2抗体检测内生水平总数胶原IV alpha2蛋白

纯度 :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

形式 :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

浓度 :

1毫克/毫升

储存稳定性 :

Store at -20 degree C for 1 year

检测过的应用 :

免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 酶联免疫吸附测定(EIA)

应用笔记 :

WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:20000

其他信息2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human Collagen IV alpha2. Pathway: Adhesion

产品种类 :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

产品引用 :

Dunham A., Nature 428:522-528(2004). Fischer G., Biochem. J. 292:687-695(1993). Kamphaus G.D., J. Biol. Chem. 275:1209-1215(2000). ------------------------------------------------------------------------------------------------------------------------------------------

NCBI GI登录号 :

116256354

NCBI登录号 :

NP_001837.2

NCBI基因登录号 :

NM_001846.2

UniProt数据库登录号 :

P08572

NCBI分子量 :

167,553 Da

NCBI信号通路 :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Axon Guidance Pathway (105688); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Formation Pathway (645288); Developmental Biology Pathway (477129); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479)

NCBI总结 :

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]

UniProt数据库总结 :

COL4A2: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A2 are the cause of porencephaly type 2 (POREN2). POREN2 is a neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles. Defects in COL4A2 are a cause of susceptibility to intracerebral hemorrhage (ICH). ICH is a pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the type IV collagen family. Protein type: Extracellular matrix; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 13q34. Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; collagen type IV; extracellular region. Molecular Function: protein binding; extracellular matrix structural constituent. Biological Process: receptor-mediated endocytosis; axon guidance; collagen catabolic process; extracellular matrix disassembly; negative regulation of angiogenesis; extracellular matrix organization and biogenesis; transcription, DNA-dependent; angiogenesis. Disease: Porencephaly 2; Hemorrhage, Intracerebral, Susceptibility To

尺寸1 :

0.1毫克

价格1 :

215美元

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