抗体

mGluR7抗体

MBS853322

0.1毫克

215美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

mGluR7抗体

mGluR7

EAA5; GLR7; GluR7a; dJ1090M5.1 (glutamate receptor; ionotropic; kainate 3 (GLUR7)); excitatory amino acid receptor 5; glutamate receptor 7 precursor

metabotropic glutamate receptor 7 isoform a; Metabotropic glutamate receptor 7; metabotropic glutamate receptor 7; protein phosphatase 1, regulatory subunit 87; glutamate receptor, metabotropic 7

mGluR7

GRM7;GRM7;GLUR7;MGLU7;GPRC1G;MGLUR7;PPP1R87;GPRC1G;MGLUR7;mGluR7

GRM7_HUMAN

兔

人类, 小鼠, 大鼠

915

GluR7抗体检测内生水平总数GluR7蛋白

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

100微克/100微升

Store at -20 degree C for 1 year

免疫印迹(免疫印迹), 免疫组化(免疫组化), 酶联免疫吸附测定(EIA)

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000

Immunogen: The antiserum was produced against synthesized peptide derived from human GluR7. Pathway: Channel

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Hans H. Schiffer, J. Neurosci., Dec 2000; 20: 9025. Nathalie Strutz, J. Neurosci., Jan 2001; 21: 401. Fr©d©ric Jaskolski, J. Biol. Chem., Jun 2005; 280: 22968 - 22976. DE Hamassaki-Britto, J. Neurosci., May 1993; 13: 1888.

4504147

NP_000835.1

NM_000844.3

Q14831

101,302 Da

Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (106381); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway (198839); Glutamatergic Synapse Pathway (213818); Glutamatergic Synapse Pathway (213811); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Signal Transduction Pathway (477114)

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3. Chromosomal Location of Human Ortholog: 3p26.1-p25.1. Cellular Component: asymmetric synapse; presynaptic membrane; postsynaptic membrane; axon; integral to plasma membrane; dendrite; integral to membrane; presynaptic active zone; plasma membrane; dendritic shaft; cell cortex; receptor complex. Molecular Function: voltage-gated calcium channel activity; group III metabotropic glutamate receptor activity; glutamate binding; calcium channel regulator activity; calcium ion binding; glutamate receptor activity; PDZ domain binding. Biological Process: behavioral fear response; regulation of synaptic transmission, glutamatergic; negative regulation of glutamate secretion; short-term memory; sensory perception of smell; negative regulation of adenylate cyclase activity; regulation of cyclase activity; transmission of nerve impulse; synaptic transmission; negative regulation of cAMP biosynthetic process; sensory perception of sound; adult behavior; conditioned taste aversion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

0.1毫克

215美元