产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
SGOL1抗体
目录 :
MBS853417
规格 :
0.1毫克
价格 :
215美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS853417
产品类型 :
抗体
产品全称 :
SGOL1抗体
产品简称 :
SGOL1
产品名称同义词 :
Shugoshin-like 1; hSgo1; Serologically defined breast cancer antigen NY-BR-85; SGO1
其他名称 :
shugoshin-like 1 isoform A1; Shugoshin-like 1; shugoshin-like 1; hSgo1; shugoshin 1AB protein; shugoshin 1CD protein; shugoshin 1EF protein; shugoshin 1GH protein; shugoshin 1KL protein; serologically defined breast cancer antigen NY-BR-85; shugoshin-like 1 (S. pombe); Serologically defined breast cancer antigen NY-BR-85
产品基因名称 :
SGOL1
其他基因名称 :
SGOL1;SGOL1;SGO;Sgo1;NY-BR-85;SGO1;hSgo1
UniProt数据库进入名 :
SGOL1_HUMAN
宿主 :
反应物种 :
人类
序列长度 :
527
特异性 :
SGOL1抗体检测内生水平总数SGOL1蛋白
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
形式 :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
储存稳定性 :
Store at -20 degree C for 1 year
检测过的应用 :
免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
WB: 1:500~1:1000, ELISA: 1:20000
其他信息2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human SGOL1. Pathway: Cell Cycle
产品种类 :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
产品引用 :
McGuinness B.E., PLoS Biol. 3:433-449(2005). Kitajima T.S., Curr. Biol. 15:353-359(2005). Tang Z., Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004). ------------------------------------------------------------------------------------------------------------------------------------------
NCBI GI登录号 :
60302875
NCBI登录号 :
NP_001012409.1
NCBI基因登录号 :
NM_001012409.2
UniProt数据库登录号 :
Q5FBB7
NCBI分子量 :
24,646 Da
NCBI信号通路 :
Aurora B Signaling Pathway (138080); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); M Phase Pathway (105812); Mitotic Anaphase Pathway (105818); Mitotic Metaphase And Anaphase Pathway (730317); Mitotic Prometaphase Pathway (105815); Oocyte Meiosis Pathway (126909); Oocyte Meiosis Pathway (126872); PLK1 Signaling Events Pathway (138007)
NCBI总结 :
The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
UniProt数据库总结 :
SGO1: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Belongs to the shugoshin family. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 3p24.3. Cellular Component: kinetochore; nucleoplasm; spindle pole; centrosome; cytoplasm; cytosol; chromosome, pericentric region; condensed nuclear chromosome, pericentric region. Molecular Function: protein binding; kinase binding. Biological Process: mitosis; cell division; mitotic cell cycle; attachment of spindle microtubules to kinetochore; meiotic chromosome segregation; centriole-centriole cohesion; chromosome segregation. Disease: Chronic Atrial And Intestinal Dysrhythmia
尺寸1 :
0.1毫克
价格1 :
215美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。