产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
EPHA4(磷酸化Tyr596)抗体
目录 :
MBS854677
规格 :
0.1毫克
价格 :
215美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS854677
产品类型 :
抗体
产品全称 :
EPHA4(磷酸化Tyr596)抗体
产品简称 :
EPHA4
产品名称同义词 :
Ephrin type-A receptor 4; EC=2.7.10.1; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK
其他名称 :
ephrin type-A receptor 4; Ephrin type-A receptor 4; ephrin type-A receptor 4; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8; EPH receptor A4; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK
产品基因名称 :
EPHA4
其他基因名称 :
EPHA4;EPHA4;SEK;HEK8;TYRO1;HEK8;SEK;TYRO1;EK8;hEK8
UniProt数据库进入名 :
EPHA4_HUMAN
宿主 :
反应物种 :
人类, 小鼠
序列长度 :
986
特异性 :
EPHA4 (Phospho-Tyr596) antibody detects endogenous levels of EPHA4 only when phosphorylated at tyrosine 596
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s
形式 :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
储存稳定性 :
Store at -20 degree C for 1 year
检测过的应用 :
免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
WB: 1:500~1:1000, ELISA: 1:20000
其他信息2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human EPHA4 around the phosphorylation site of tyrosine 596. All Sites: Human: Tyr596; Mouse: Tyr596. Pathway: Phospho-specific
产品种类 :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
产品引用 :
Rikova K., Cell 131:1190-1203(2007) [PubMed: 18083107]. Richter M., J. Neurosci. 27:14205-14215(2007) [PubMed: 18094260]. Fu W.Y., Nat. Neurosci. 10:67-76(2007) [PubMed: 17143272]. ----------------------------------------------------------------------------
NCBI GI登录号 :
4758280
NCBI登录号 :
NP_004429.1
NCBI基因登录号 :
NM_004438.3
UniProt数据库登录号 :
P54764
NCBI分子量 :
104,507 Da
NCBI信号通路 :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1016174); EPH-ephrin Mediated Repulsion Of Cells Pathway (1016178); EPHA Forward Signaling Pathway (138041); EPHA-mediated Growth Cone Collapse Pathway (1016175); EphrinA-EPHA Pathway (137942); Spinal Cord Injury Pathway (739007)
NCBI总结 :
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Protein type: EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; TK group; Eph family. Chromosomal Location of Human Ortholog: 2q36.1. Cellular Component: Golgi apparatus; cell surface; integral to plasma membrane; endoplasmic reticulum; postsynaptic density; dendrite; dendritic spine; perikaryon; postsynaptic membrane; mitochondrial outer membrane; axon; early endosome membrane; cytoplasm; plasma membrane; nerve terminal; neuromuscular junction; cell junction; filopodium. Molecular Function: identical protein binding; protein binding; ephrin receptor binding; transmembrane-ephrin receptor activity; GPI-linked ephrin receptor activity; PH domain binding; ATP binding; protein kinase activity. Biological Process: axon guidance; positive regulation of JNK activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; protein amino acid autophosphorylation; regulation of astrocyte differentiation; motor axon guidance; positive regulation of dendrite morphogenesis; glial cell migration; regulation of axonogenesis; adult walking behavior; ephrin receptor signaling pathway; cell adhesion; corticospinal tract morphogenesis
尺寸1 :
0.1毫克
价格1 :
215美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。