抗体

cofilin1(磷酸化Tyr139)抗体

MBS856748

0.1毫克

215美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

cofilin1(磷酸化Tyr139)抗体

cofilin1

cofilin-1; Cofilin-1; cofilin-1; p18; 18 kDa phosphoprotein; cofilin, non-muscle isoform; epididymis secretory protein Li 15; cofilin 1 (non-muscle); 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform

CFL1;CFL1;CFL;HEL-S-15;CFL;p18

COF1_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

166

cofilin1 (phospho-Tyr139) Antibody detects endogenous levels of cofilin1 only when phosphorylated at tyrosine 139.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

50微克/50微升

Store at -20 degree C for 1 year

免疫组化(免疫组化)

IHC: 1:50~100

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human cofilin1 around the phosphorylation site of tyrosine 139 (N-C-YP-E-E). Pathway: Cytoskeletal/Adhesion

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Carlier, M. et al. (1999) J. Biol. Chem. 274, 33827-33830. Arber, S. et al. (1998) Nature 393, 805-809. Yang, N. et al. (1998) Nature 393, 809-812.

5031635

NP_005498.1

NM_005507.2

P23528

18,502 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); BDNF Signaling Pathway (712093); CDC42 Signaling Events Pathway (137994); CXCR4-mediated Signaling Events Pathway (137910); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1016174); EPHB-mediated Forward Signaling Pathway (1016176); Fc Gamma R-mediated Phagocytosis Pathway (114228)

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: extracellular space; cortical actin cytoskeleton; nuclear matrix; focal adhesion; membrane; cytoplasm; intercellular junction; nucleus; vesicle. Molecular Function: protein binding; actin binding. Biological Process: axon guidance; platelet activation; actin filament depolymerization; positive regulation of actin filament depolymerization; response to virus; negative regulation of cell size; cytoskeleton organization and biogenesis; response to amino acid stimulus; protein amino acid phosphorylation; Rho protein signal transduction; neural fold formation; platelet degranulation; cytokinesis after mitosis; protein import into nucleus; establishment of cell polarity; ephrin receptor signaling pathway; innate immune response; regulation of cell morphogenesis; actin cytoskeleton organization and biogenesis; blood coagulation; neural crest cell migration; negative regulation of apoptosis

0.1毫克

215美元

0.05毫克

225