抗体

FLT3(磷酸化Tyr591)抗体

MBS857131

0.1毫克

215美元

多克隆

兔

未共轭

免疫印迹, 免疫组化

抗体

FLT3(磷酸化Tyr591)抗体

FLT3

receptor-type tyrosine-protein kinase FLT3; Receptor-type tyrosine-protein kinase FLT3; receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III; fms-related tyrosine kinase 3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135

FLT3

FLT3;FLT3;FLK2;STK1;CD135;FLK-2;CD135;FLK2;STK1;FLK-2;FLT-3;STK-1

FLT3_HUMAN

多克隆

IgG

兔

人类

993

FLT3 (Phospho-Tyr591) antibody detects endogenous levels of FLT3 only when phosphorylated at tyrosine 591.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

50微克/50微升

Store at -20 degree C for 1 year

免疫印迹(免疫印迹), 免疫组化(免疫组化)

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:4000

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human FLT3 around the phosphorylation site of tyrosine 591 (Y-F-YP-V-D). Pathway: Ras/Raf/MAPK and PI3 kinase

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Irish JM, et al. (2007) Blood 109, 2589-96. Heiss E, et al. (2006) Blood 108, 1542-50. Shurin, M.R. et al. (1998) Cytokine Growth Factor Rev. 9, 37-48. Naoe, T. et al. (2001) Cancer Chemother. Pharmacol. 48 Suppl1, S27-S30. Namikawa, R. et al. (1996) Stem Cells 14, 388-395. Zhang, S. et al. (1999) J. Leukoc. Biol. 65, 372-380.

121114304

NP_004110.2

NM_004119.2

P36888

108,378 Da

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Pathways In Cancer (83105); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]

FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; Oncoprotein; EC 2.7.10.1; TK group; PDGFR family. Chromosomal Location of Human Ortholog: 13q12. Cellular Component: protein complex; endoplasmic reticulum lumen; integral to plasma membrane; cytosol; nucleus; external side of plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; vascular endothelial growth factor receptor activity; protein binding; protein homodimerization activity; protein complex binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; glucocorticoid receptor binding. Biological Process: negative regulation of B cell differentiation; pro-B cell differentiation; lymphocyte proliferation; organ regeneration; peptidyl-tyrosine phosphorylation; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; response to organic nitrogen; regulation of apoptosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of tyrosine phosphorylation of STAT protein; myeloid progenitor cell differentiation; B cell differentiation; positive regulation of cell proliferation; hemopoiesis; pro-T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; leukocyte homeostasis. Disease: Leukemia, Acute Lymphoblastic

0.1毫克

215美元

0.05毫克

225