抗体

HNF4甲(Ab-304)抗体

MBS857145

0.05毫克

180美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

HNF4甲(Ab-304)抗体

HNF4甲

HNF4a(Ab-304)抗体

hepatocyte nuclear factor 4-alpha isoform HNF4alpha2; Hepatocyte nuclear factor 4-alpha; hepatocyte nuclear factor 4-alpha; TCF-14; HNF4alpha10/11/12; transcription factor 14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1; hepatocyte nuclear factor 4, alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4

HNF4

HNF4A;HNF4A;TCF;HNF4;MODY;FRTS4;MODY1;NR2A1;TCF14;HNF4a7;HNF4a8;HNF4a9;NR2A21;HNF4alpha;HNF4;NR2A1;TCF14;HNF-4-alpha;TCF-14

HNF4A_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

474

HNF4alpha(Ab-304)抗体检测内生水平总数HNF4alpha蛋白

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

50微克/50微升

Store at -20 degree C for 1 year

免疫组化(免疫组化)

IHC: 1:50~1:100

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human HNF4alpha around the phosphorylation site of serine 304(L-R-SP-Q-V). Pathway: Chromatin/Transcription

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Cicchini C,et al. (2006) J Cell Physiol. 209(1):230-8. Maeda Y,et al.(2006)Biochem J. 400(2):303-13. Li K,et al.(2006)J Cell Biochem. 99(2):558-64.

31077205

NP_000448.3

NM_000457.4

P41235

43,988 Da

AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Developmental Biology Pathway (477129); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); HIF-1-alpha Transcription Factor Network Pathway (138045); Integrated Pancreatic Cancer Pathway (711360); Maturity Onset Diabetes Of The Young Pathway (83096)

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described. Protein type: DNA-binding; Nuclear receptor; Transcription factor. Chromosomal Location of Human Ortholog: 20q13.12. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; DNA binding; zinc ion binding; steroid hormone receptor activity; transcription factor activity; fatty acid binding; receptor binding. Biological Process: transcription initiation from RNA polymerase II promoter; regulation of lipid metabolic process; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; lipid homeostasis; glucose homeostasis; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of gastrulation; xenobiotic metabolic process; response to glucose stimulus; ornithine metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of cell growth; lipid metabolic process; blood coagulation; sex differentiation; regulation of insulin secretion; phospholipid homeostasis. Disease: Fanconi Renotubular Syndrome 4 With Maturity-onset Diabetes Of The Young; Maturity-onset Diabetes Of The Young, Type 1; Diabetes Mellitus, Noninsulin-dependent

0.05毫克

180美元

0.1毫克

215