抗体

PLC丙1(磷酸化Tyr783)抗体

MBS857171

0.1毫克

215美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

PLC丙1(磷酸化Tyr783)抗体

PLC丙1

PLCg1(磷酸化Tyr783)抗体

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-gamma-1; phospholipase C-II; phospholipase C-148; phosphoinositidase C; phospholipase C-gamma-1; inositoltrisphosphohydrolase; phosphoinositide phospholipase C; phosphatidylinositol phospholipase C; triphosphoinositide phosphodiesterase; phosphoinositide phospholipase C-gamma-1; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; phospholipase C, gamma 1 (formerly subtype 148); 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; phospholipase C, gamma 1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1

PLC丙1

PLCG1;PLCG1;PLC1;NCKAP3;PLC-II;PLC148;PLCgamma1;PLC1;PLC-II;PLC丙

PLCG1_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

1291

PLCgamma1 (phospho-Tyr783) antibody detects endogenous levels of PLCgamma1 only when phosphorylated at tyrosine 783.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

50微克/50微升

Store at -20 degree C for 1 year

免疫印迹(免疫印迹)

WB: 1:500~1:1000

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human PLCgamma1 around the phosphorylation site of tyrosine 783 (G-F-YP-V-E). Pathway: NF-kappa B, Receptors, Kinase/Phosphatases

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

DeBell KE, et al. Mol Cell Biol. 1999 Nov; 19(11): 7388-7398. Ver- MC, et al. Mol Cell Biol. 2001 Oct; 21(20): 6939-6950. Sette C, et al. EMBO J. 2002 Oct 15; 21(20): 5386-5395.

33598948

NP_002651.2

NM_002660.2

P19174

148,660 Da

Adaptive Immune System Pathway (366160); Angiogenesis Pathway (198772); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Axon Guidance Pathway (105688); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cell Surface Interactions At The Vascular Wall Pathway (106062)

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PLCG1: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 20q12-q13.1. Cellular Component: signalosome; ruffle; cell projection; lamellipodium; cytoplasm; plasma membrane; intercellular junction; cytosol. Molecular Function: protein binding; glutamate receptor binding; neurotrophin TRKA receptor binding; receptor signaling protein activity; calcium ion binding; receptor tyrosine kinase binding; protein kinase binding; phospholipase C activity; phosphoinositide phospholipase C activity. Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; cell migration; inositol phosphate metabolic process; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; viral reproduction; phospholipid catabolic process; in utero embryonic development; cytokine and chemokine mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; calcium-mediated signaling; signal transduction; T cell receptor signaling pathway; positive regulation of angiogenesis; phospholipase C activation; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration

0.1毫克

215美元

0.05毫克

225