产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
CD8
目录 :
MBS857197
规格 :
0.1毫升
价格 :
280美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
小鼠
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS857197 图像 1
Western blot analysis on mouse Thymus using anti-CD8 polyclonal antibody
产品信息
目录号 :
MBS857197
产品类型 :
抗体
产品全称 :
CD8
产品简称 :
[CD8]
产品名称同义词 :
[T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; CD8a]
其他名称 :
[T-cell surface glycoprotein CD8 alpha chain isoform 1; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; CD8 antigen, alpha chain; T-cell surface glycoprotein Lyt-2; CD_antigen: CD8a]
产品基因名称 :
[CD8]
产品基因名称同义词 :
[CD8A]
其他基因名称 :
[Cd8a; Cd8a; Ly-2; Ly-B; Ly-35; Lyt-2; BB154331; Lyt-2; Lyt2]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
小鼠
序列长度 :
247
特异性 :
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to near N-terminal residues of Cd8a protein.
纯度 :
免疫原亲和纯化
形式 :
液体;1*TBS(pH7.4), 0.5% BSA, 25% 甘油
浓度 :
100微升, 0.45毫克/毫升
储存稳定性 :
Store at +4 degree C after thawing. Aliquot store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 免疫细胞化学(免疫细胞化学)
应用笔记 :
WB: 1:500
image1头 :
免疫印迹
其它信息1 :
Immunogen: Peptide. Storage Buffer: 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
其他信息2 :
Positive control: Mouse Thymus. Cellular Location: Cell membrane. Preservative: 0.05% Sodium Azide.
产品描述 :
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated a and ~ subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. CD8 is thought to playa role in the process ofT-ceil mediated killing.
NCBI GI登录号 :
124487437
NCBI登录号 :
NP_001074579.1
NCBI基因登录号 :
NM_001081110.2
UniProt数据库登录号 :
P01731
NCBI分子量 :
32-36kDa
NCBI信号通路 :
Adaptive Immune System Pathway (1110669); Antigen Processing And Presentation Pathway (83271); Antigen Processing And Presentation Pathway (485); Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (1110668); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1110695); Primary Immunodeficiency Pathway (83318)
UniProt数据库总结 :
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
尺寸1 :
0.1毫升
价格1 :
280美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。