抗体

alpha-catenin (Ab-641) antibody

MBS857401

0.05毫克

180美元

多克隆

兔

未共轭

人类, 小鼠

抗体

alpha-catenin (Ab-641) antibody

alpha-catenin

catenin alpha-1 isoform 2; Catenin alpha-1; catenin alpha-1; alpha-catenin; alphaE-catenin; alpha E-catenin; alpha-E-catenin; renal carcinoma antigen NY-REN-13; cadherin-associated protein,102kDa; catenin (cadherin-associated protein), alpha 1, 102kDa; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13

CTNNA1;CTNNA1;CAP102

CTNA1_HUMAN

多克隆

IgG

兔

人类, 小鼠

841

alpha-catenin (Ab-641) antibody detects endogenous levels of total alpha-catenin protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

50微克/50微升

Store at -20 degree C for 1 year

免疫印迹(免疫印迹)

WB: 1:500~1:1000

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human alpha-catenin around the phosphorylation site of serine 641 (D-D-SP-D-F). Pathway: Wnt/beta-catenin

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Hwang, S.G. et al. (2005) J. Biol. Chem. 280, 12758-12765. Drees, F. et al. (2005) Cell 123, 903-915. Yamada, S. et al. (2005) Cell 123, 889-901. Kobielak, A. and Fuchs, E. (2004) Nat. Rev. Mol. Cell Biol. 5, 614-625.

594140506

NP_001277236.1

NM_001290307.1

P35221

59,550 Da

Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Adherens Junctions Interactions Pathway (119533); Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); CDC42 Signaling Events Pathway (137994)

CTNNA1: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4 and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma- catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F- actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1. Expressed ubiquitously in normal tissues. Belongs to the vinculin/alpha-catenin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Actin-binding; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 5q31.2. Cellular Component: focal adhesion; lamellipodium; plasma membrane; acrosome; intercellular junction; catenin complex; zonula adherens; cytosol; actin cytoskeleton. Molecular Function: actin filament binding; protein binding; cadherin binding; gamma-catenin binding; beta-catenin binding; structural molecule activity; vinculin binding. Biological Process: intercellular junction assembly and maintenance; apical junction assembly; gap junction assembly; protein heterooligomerization; axon regeneration; male gonad development; establishment and/or maintenance of cell polarity; actin filament organization; odontogenesis of dentine-containing teeth; muscle cell differentiation; ovarian follicle development; negative regulation of neuroblast proliferation; response to estrogen stimulus; positive regulation of smoothened signaling pathway; positive regulation of muscle cell differentiation; cell adhesion; vascular endothelial growth factor receptor signaling pathway; aging

0.05毫克

180美元

0.1毫克

215