抗体

整合素乙3抗体

MBS857761

0.1毫克

310美元

单克隆

小鼠

未共轭

抗体

整合素乙3抗体

整合素乙3

BDPLT2; CD 61; CD61; CD61 antigen; GP3A; GPIIIa; GT; HPA 1; HPA 4; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61); Integrin beta chain beta 3; Integrin beta-3; ITB3_HUMAN; ITG B3; ITGB 3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; platelet glycoprotein IIIa precursor; Platelet membrane glycoprotein IIIa; PTP;

人整合素, 乙3(血小板糖蛋白Ⅲa, 抗原CD61)(ITGB3), mRNA;整合素乙3;整合素乙3;血小板膜糖蛋白IIIa;整合素, 乙3(血小板糖蛋白Ⅲa, 抗原CD61);血小板膜糖蛋白IIIa;糖蛋白Ⅲa;CD_antigen:CD61

ITGB3;ITGB3;GT;CD61;GP3A;BDPLT2;糖蛋白Ⅲa;BDPLT16;GP3A;糖蛋白Ⅲa

ITB3_HUMAN

单克隆

IgG1

小鼠

人类

4894

This antibody detects endogenous levels of ITGB3 and does not cross-react with related proteins.

亲和纯化

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

免疫印迹(免疫印迹)

Uniprot Summary: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi´s sarcoma lesions.

Immunogen: Purified recombinant human ITGB3 protein fragments expressed in E.coli. Entrez Summary: The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]. Cellular Localization: Nucleus, Note: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

47078291

NP_000203.2

NM_000212

120kDa

Arf6 Signaling Events Pathway (138034); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Cell Surface Interactions At The Vascular Wall Pathway (106062); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM Proteoglycans Pathway (833812)

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: filopodium membrane; platelet alpha granule membrane; cell surface; focal adhesion; microvillus membrane; integral to plasma membrane; melanosome; plasma membrane; integrin complex; nucleus; receptor complex. Molecular Function: identical protein binding; protein binding; protease binding; vascular endothelial growth factor receptor 2 binding; extracellular matrix binding; fibronectin binding; platelet-derived growth factor receptor binding; protein disulfide isomerase activity; cell adhesion molecule binding; receptor activity. Biological Process: negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; wound healing; protein folding; cell-matrix adhesion; smooth muscle cell migration; negative chemotaxis; mesodermal cell differentiation; positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet degranulation; cell-substrate junction assembly; cell growth; cell adhesion; integrin-mediated signaling pathway; platelet activation; cell migration; regulation of bone resorption; negative regulation of lipoprotein metabolic process; angiogenesis involved in wound healing; cell-substrate adhesion; heterotypic cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; blood coagulation; tube development; vascular endothelial growth factor receptor signaling pathway; leukocyte migration. Disease: Myocardial Infarction, Susceptibility To; Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16

0.1毫克

310美元