产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
转化生长因子β受体I(磷酸化Ser165)抗体
目录 :
MBS859620
规格 :
0.1毫克
价格 :
215美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS859620
产品类型 :
抗体
产品全称 :
转化生长因子β受体I(磷酸化Ser165)抗体
产品简称 :
转化生长因子β受体I
产品名称同义词 :
TGF b Receptor I (Phospho-Ser165) Antibody; ADRB2; ALK-5; Activin receptor-like kinase 5; ESK2; SKR4; TGF-beta receptor type I precursor; TGF-beta type I receptor; TGF-betaR1; TGFR-1; TGFR1; kinase TGF-beta-R1; receptor R4
其他名称 :
TGF-beta receptor type-1 isoform 2; TGF-beta receptor type-1; TGF-beta receptor type-1; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin receptor-like kinase 5; multiple self-healing squamous epithelioma; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; transforming growth factor-beta receptor type I; activin A receptor type II-like protein kinase of 53kD; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); transforming growth factor, beta receptor 1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
其他基因名称 :
TGFBR1; TGFBR1; AAT5; ALK5; ESS1; LDS1; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I
UniProt数据库进入名 :
TGFR1_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
426
特异性 :
TGF beta Receptor I (Phospho-Ser165) antibody detects endogenous levels of TGF beta Receptor I only when phosphorylated at serine 165.
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
形式 :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20 degree C for 1 year
检测过的应用 :
免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
IF: 1:100~1:500, ELISA: 1:5000
其他信息2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human TGF beta Receptor I around the phosphorylation site of serine 165 (D-P-SP-L-D). All Sites: Human: Ser165; Mouse: Ser165; Rat: Ser163
产品种类 :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
产品引用 :
Franzen P., Cell 75:681-692(1993). Vellucci V.F., Genomics 46:278-283(1997). Lynch M.A., Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. ----------------------------------------------------------------------------
NCBI GI登录号 :
195963412
NCBI登录号 :
NP_001124388.1
NCBI基因登录号 :
NM_001130916.1
UniProt数据库登录号 :
P36897
NCBI分子量 :
47,690 Da
NCBI信号通路 :
ALK1 Signaling Events Pathway (137968); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518); Cytokine-cytokine Receptor Interaction Pathway (83051)
NCBI总结 :
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt数据库总结 :
TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart. Protein type: Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Kinase, protein; Receptor, misc.; TKL group; STKR family; Type1 subfamily. Chromosomal Location of Human Ortholog: 9q22. Cellular Component: tight junction; membrane; cell; plasma membrane; endosome; receptor complex. Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; growth factor binding; metal ion binding; receptor signaling protein activity; punt binding; SMAD binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity. Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; heart development; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; cell motility involved in cell locomotion; activin receptor signaling pathway; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; kidney development; cell cycle arrest; neuron fate commitment; embryonic cranial skeleton morphogenesis; parathyroid gland development; positive regulation of cell growth; endothelial cell activation; mesenchymal cell differentiation; regulation of gene expression; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of endothelial cell proliferation; lens development in camera-type eye; wound healing; apoptosis; regulation of protein ubiquitination; palate development; signal transduction; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; skeletal morphogenesis; regulation of protein binding; epithelial to mesenchymal transition; artery morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway. Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
尺寸1 :
0.1毫克
价格1 :
215美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。