产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
TFEB多克隆抗体
目录 :
MBS9125929
规格 :
0.05毫升
价格 :
230美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
产品信息
目录号 :
MBS9125929
产品类型 :
抗体
产品全称 :
TFEB多克隆抗体
产品简称 :
TFEB
产品名称同义词 :
TCFEB;BHLHE35;ALPHATFEB
其他名称 :
Transcription factor EB; Transcription factor EB; transcription factor EB; T-cell transcription factor EB; class E basic helix-loop-helix protein 35; transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35
产品基因名称 :
TFEB
其他基因名称 :
TFEB;TFEB;TCFEB;BHLHE35;ALPHATFEB;BHLHE35;bHLHe35
UniProt数据库进入名 :
TFEB_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
476
纯度 :
亲和纯化
储存稳定性 :
Store at -20 degree C. Avoid freeze / thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF)
应用笔记 :
WB: 1:500 - 1:2000。 IHC: 1:50 - 1:200。 IF: 1:50 - 1:100
其它信息1 :
Species: Human. Category: Primary antibody
其他信息2 :
Immunogen: Recombinant protein of human TFEB. Calculated Molecular Weight: 53kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
产品种类 :
多克隆
NCBI GI登录号 :
19856774
NCBI登录号 :
P19484.3
UniProt数据库登录号 :
P19484
NCBI分子量 :
53kDa
UniProt数据库总结 :
TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3 -CANNTG-5 ). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5 -GTCACGTGAC-3 ) present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: cytoplasm; nucleus. Molecular Function: protein dimerization activity; transcription factor activity. Biological Process: embryonic placenta development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; lysosome organization and biogenesis; autophagy; positive regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; humoral immune response
尺寸1 :
0.05毫升
价格1 :
230美元
尺寸2 :
0.1毫升
价格2 :
305
size3 :
0.2毫升
价格3 :
460
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。