抗体

F2R

MBS9127538

0.05毫升

200美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

F2R

[F2R]

[F2R;CF2R;HTR;PAR-1;PAR1;TR;蛋白酶激活受体]

[蛋白酶激活受体;蛋白酶激活受体;蛋白酶激活受体;蛋白酶激活受体1;凝血因子II(凝血酶)受体;凝血因子II受体;凝血酶受体]

[F2R]

[F2R;F2R;TR;HTR;CF2R;PAR1;PAR-1;CF2R;PAR1;TR;PAR-1]

PAR1_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

425

亲和纯化

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

存放在-20°C。 避免反复冷冻/解冻

免疫印迹(免疫印迹)

WB:1:500-1:2000

免疫印迹(免疫印迹)

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 42-110 of human F2R (NP_001983.2).

多克隆

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants.

20178318

P25116.2

P25116

Calculated: 47kDa. Observed: 47kDa

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Common Pathway (106060); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); Endocytosis Pathway (102279)

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]

PAR1: a G-protein coupled high-affinity receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelet activation and in vascular development. Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; Cell development/differentiation. Chromosomal Location of Human Ortholog: 5q13. Cellular Component: Golgi apparatus; postsynaptic membrane; integral to plasma membrane; early endosome; plasma membrane; extracellular region; caveola; neuromuscular junction. Molecular Function: G-protein coupled receptor activity; protein binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; thrombin receptor activity; receptor binding. Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of blood coagulation; activation of MAPKK activity; negative regulation of glomerular filtration; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; positive regulation of JAK-STAT cascade; positive regulation of caspase activity; response to lipopolysaccharide; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; connective tissue replacement during inflammatory response; positive regulation of MAPKKK cascade; platelet dense granule organization and biogenesis; regulation of interleukin-1 beta production; protein kinase C activation; positive regulation of cell proliferation; response to wounding; positive regulation of smooth muscle contraction; negative regulation of neuron apoptosis; establishment of synaptic specificity at neuromuscular junction; inflammatory response; STAT protein nuclear translocation; caspase activation; platelet activation; anatomical structure morphogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of Rho protein signal transduction; positive regulation of phosphoinositide 3-kinase cascade; tyrosine phosphorylation of STAT protein; G-protein coupled receptor protein signaling pathway; homeostasis of number of cells within a tissue; release of sequestered calcium ion into cytosol; regulation of blood coagulation; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of calcium ion transport; blood coagulation; positive regulation of cell migration

0.05毫升

200美元

0.1毫升

275

0.2毫升

430