抗体

Ras相关C3肉毒杆菌毒素底物1多克隆抗体

MBS9127955

0.05毫升

200美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

Ras相关C3肉毒杆菌毒素底物1多克隆抗体

[Ras相关C3肉毒杆菌毒素底物1]

[RAC1; MIG5; Rac-1; TC-25; p21-Rac1; ras-related C3 botulinum toxin substrate 1]

[ras-related C3 botulinum toxin substrate 1 isoform Rac1; Ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1]

[Ras相关C3肉毒杆菌毒素底物1]

[RAC1; RAC1; MIG5; Rac-1; TC-25; p21-Rac1; TC25]

RAC1_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

211

亲和纯化

存放在-20°C。 避免反复冷冻/解冻

Western Blot (WB), Immunohistochemistry (IHC), Immunofluoresence (IF)

免疫印迹1:500-1:2000。 免疫组化1:50-1:200。 IF 1:50 - 1:100

免疫印迹(免疫印迹)

免疫组化(免疫组化)

免疫荧光(IF)

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human RAC1 (NP_008839.2). Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

9845511

NP_008839.2

NM_006908.4

P63000

AGE/RAGE Pathway (698754); Activation Of Rac Pathway (1270321); Adaptive Immune System Pathway (1269171); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Alpha6-Beta4 Integrin Signaling Pathway (198807); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Androgen Receptor Signaling Pathway (198806)

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

RAC1: a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described. Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein; G protein, monomeric, Rho. Chromosomal Location of Human Ortholog: 7p22. Cellular Component: extrinsic to plasma membrane; Golgi membrane; focal adhesion; membrane; lamellipodium; cytoplasm; plasma membrane; melanosome; actin filament; trans-Golgi network; cytosol; phagocytic cup. Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; GTP-dependent protein binding; thioesterase binding; Rho GDP-dissociation inhibitor binding; protein kinase binding; Rab GTPase binding. Biological Process: nerve growth factor receptor signaling pathway; viral reproduction; positive regulation of apoptosis; metabolic process; cell motility involved in cell locomotion; regulation of cell migration; small GTPase mediated signal transduction; positive regulation of stress fiber formation; cell adhesion; bone resorption; platelet activation; anatomical structure morphogenesis; mast cell chemotaxis; dendrite morphogenesis; positive regulation of Rho protein signal transduction; regulation of defense response to virus by virus; negative regulation of interleukin-23 production; T cell costimulation; cerebral cortex radially oriented cell migration; actin cytoskeleton organization and biogenesis; axon guidance; cell-matrix adhesion; localization within membrane; positive regulation of focal adhesion formation; actin filament polymerization; ephrin receptor signaling pathway; response to wounding; inflammatory response; regulation of hydrogen peroxide metabolic process; lamellipodium biogenesis; intercellular junction assembly and maintenance; embryonic olfactory bulb interneuron precursor migration; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of phosphoinositide 3-kinase activity; engulfment of apoptotic cell; G-protein coupled receptor protein signaling pathway; cell proliferation; hyperosmotic response; positive regulation of actin filament polymerization; organization of an anatomical structure; auditory receptor cell morphogenesis; ruffle organization and biogenesis; innate immune response; negative regulation of receptor-mediated endocytosis; positive regulation of protein amino acid phosphorylation; cell motility; blood coagulation; vascular endothelial growth factor receptor signaling pathway; positive regulation of DNA replication

0.05毫升

200美元

0.1毫升

275

0.2毫升

430