抗体

CA9 Polyclonal Antibody

MBS9129810

0.05毫升

200美元

多克隆

unidentified

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化

抗体

CA9 Polyclonal Antibody

[CA9]

[MN;CAIX]

[carbonic anhydrase 9; Carbonic anhydrase 9; carbonic anhydrase 9; carbonic anhydrase 9; Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1]

[CA9]

[CA9; CA9; MN; CAIX; G250; MN; CA-IX; CAIX; RCC-associated antigen G250]

CAH9_HUMAN

多克隆

IgG

未知

小鼠, 大鼠

459

亲和纯化

Store at -20 degree C. Avoid freeze / thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化)

WB: 1:500 - 1:2000。 IHC: 1:50-1:200

免疫印迹(免疫印迹)

Source: Rabbit. Immunogen: Recombinant protein of human CA9

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

多克隆

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

169636420

NP_001207.2

NM_001216.2

Q16790

50kDa

Cellular Response To Hypoxia Pathway (1270415); Cellular Responses To Stress Pathway (1270414); HIF-1-alpha Transcription Factor Network Pathway (138045); Metabolism Pathway (1269956); Nitrogen Metabolism Pathway (83025); Nitrogen Metabolism Pathway (416); Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway (1270416); Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway (1270419); Reversible Hydration Of Carbon Dioxide Pathway (1270229)

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]

CA9: Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Forms oligomers linked by disulfide bonds. By hypoxia. Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Belongs to the alpha-carbonic anhydrase family. Protein type: Nucleolus; Membrane protein, integral; EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase. Chromosomal Location of Human Ortholog: 9p13.3. Cellular Component: basolateral plasma membrane; integral to membrane; microvillus membrane; nucleolus; plasma membrane. Molecular Function: carbonate dehydratase activity; zinc ion binding. Biological Process: bicarbonate transport; morphogenesis of an epithelium; one-carbon compound metabolic process; response to drug; response to testosterone stimulus; secretion

0.05毫升

200美元

0.1毫升

275

0.2毫升

430