抗体

PRKCA Monoclonal Antibody

MBS9131320

0.05毫升

275美元

单克隆

unidentified

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

抗体

PRKCA Monoclonal Antibody

[PRKCA]

[AAG6;PKC甲;PKCA;PRKACA]

[蛋白激酶Cα类型;蛋白激酶Cα类型;蛋白激酶Cα类型;蛋白激酶Cα]

[PRKCA]

[PRKCA;PRKCA;AAG6;PKCA;PRKACA;PKC甲;PKCA;PRKACA;PKC-A;PKC甲]

单克隆

IgG

未知

人类, 小鼠, 大鼠

672

亲和纯化

Store at -20 degree C. Avoid freeze/thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 免疫沉淀(免疫沉淀)

WB: 1:500 - 1:2000。 IHC: 1:50 - 1:200。 IF: 1:50 - 1:200。 IP: 1:20 - 1:50

免疫印迹(免疫印迹)

免疫组化(免疫组化)

免疫组化(免疫组化)

免疫组化(免疫组化)

Immunohistochemistry of paraffin-embedded mouse intestin using PRKCA antibody at dilution of 1:100 (40x lens).

免疫组化(免疫组化)

Immunohistochemistry of paraffin-embedded mouse heart using PRKCA antibody at dilution of 1:100 (40x lens).

Source: Rabbit. Immunogen: Recombinant protein of human PRKCA

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

一抗

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

317373571

P17252.4

P17252

77kDa

AGE/RAGE Pathway (698754); ATF-2 Transcription Factor Network Pathway (138006); Acetylcholine Regulates Insulin Secretion Pathway (105924); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Alpha6-Beta4 Integrin Signaling Pathway (198807)

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators. Protein type: AGC group; Alpha subfamily; EC 2.7.11.13; Kinase, protein; Oncoprotein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor). Chromosomal Location of Human Ortholog: 17q24.2. Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; plasma membrane. Molecular Function: calcium-dependent protein kinase C activity; enzyme binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity. Biological Process: adenylate cyclase activation; axon guidance; mitotic nuclear envelope disassembly; negative regulation of adenylate cyclase activity; peptidyl-serine phosphorylation; platelet activation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; regulation of insulin secretion; regulation of mRNA stability

0.05毫升

275美元

0.1毫升

430

0.2毫升

655