抗体

PTPN13多克隆抗体

MBS9133056

0.05毫升

200美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

PTPN13多克隆抗体

[PTPN13]

[PTPN13; FAP-1; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE; hPTP1E; tyrosine-protein phosphotase non-receptor type 13]

[tyrosine-protein phosphatase non-receptor type 13 isoform 2; Tyrosine-protein phosphatase non-receptor type 13; tyrosine-protein phosphatase non-receptor type 13; protein tyrosine phosphatase, non-receptor type 13; Fas-associated protein-tyrosine phosphatase 1; FAP-1; PTP-BAS; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1]

[PTPN13]

[PTPN13;PTPN13;PNP1;FAP-1;PTP1E;PTPL1;PTPLE;PTP-BL;hPTP1E;PTP-BAS;PNP1;PTP1E;PTPL1;FAP-1;PTP-E1;hPTPE1]

多克隆

IgG

兔

人类, 小鼠, 大鼠

亲和纯化

PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Store at -20 degree C. Avoid freeze / thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF)

WB: 1:500 - 1:2000。 IHC: 1:50 - 1:100。 IF: 1:50 - 1:100

免疫印迹(免疫印迹)

Category: Polyclonal Antibodies. Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1).

多克隆抗体

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

5453992

NP_006255.1

NM_006264.2

Q12923

Calculated: 255kDa; 274kDa; 276kDa; 277kDa. Observed: 310kDa

Apoptosis Modulation And Signaling Pathway (198822); Ephrin B Reverse Signaling Pathway (138052); Fc-epsilon Receptor I Signaling In Mast Cells Pathway (138050)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).

0.05毫升

200美元

0.1毫升

275

0.2毫升

430