产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
CCL5多克隆抗体
目录 :
MBS9134202
规格 :
0.05毫升
价格 :
200美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS9134202
产品类型 :
抗体
产品全称 :
CCL5多克隆抗体
产品简称 :
[CCL5]
产品名称同义词 :
[D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228]
其他名称 :
[C-C motif chemokine 5 isoform 1; C-C motif chemokine 5; C-C motif chemokine 5; C-C motif chemokine ligand 5; EoCP; Eosinophil chemotactic cytokine; SIS-delta; Small-inducible cytokine A5; T cell-specific protein P228; TCP228]
产品基因名称 :
[CCL5]
其他基因名称 :
[CCL5; CCL5; SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; D17S136E; SCYA5; TCP228]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
91
序列 :
SPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAV
VFVTRKNRQVCANPEKKWVREYINSLEMS
VFVTRKNRQVCANPEKKWVREYINSLEMS
纯度 :
亲和纯化
储存稳定性 :
Store at -20 degree C. Avoid freeze / thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
WB: 1:500 - 1:2000
其它信息1 :
Immunogen: Recombinant funsion protein containing a sequence corresponding to amino acid 24-91 of human CCL5. Immunogen Species: Human
其他信息2 :
Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Cellular Location: Secreted
产品种类 :
多克隆抗体
产品描述 :
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
NCBI GI登录号 :
22538814
NCBI登录号 :
NP_002976.2
NCBI基因登录号 :
NM_002985.2
UniProt数据库登录号 :
P13501
NCBI分子量 :
9kDa
NCBI信号通路 :
Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833)
NCBI总结 :
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
UniProt数据库总结 :
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
尺寸1 :
0.05毫升
价格1 :
200美元
尺寸2 :
0.1毫升
价格2 :
275
size3 :
0.2毫升
价格3 :
430
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。