抗体

Toll样受体3抗体

MBS9200129

0.08毫升

165美元

单克隆

小鼠

未共轭

[303CT19.9。 2]

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

Toll样受体3抗体

[Toll样受体3]

[Toll样受体3;CD283;Toll样受体3]

[Toll样受体3;Toll样受体3;Toll样受体3;Toll样受体3;CD_antigen:CD283]

[Toll样受体3]

[Toll样受体3;Toll样受体3;CD283;IIAE2]

TLR3_HUMAN

单克隆

IgM, k

[303CT19.9。 2]

小鼠

人类, 小鼠

904

This TLR3 monoclonal antibody is generated from mouse immunized with TLR3 recombinant protein.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

WB~~1:100

免疫印迹(免疫印迹)

免疫印迹(免疫印迹)

Function: Key component of innate and adaptiveimmunity. TLRs (Toll-like receptors) controlhost immune response against pathogensthrough recognition of molecular patterns specific to microorganisms. TLR3 is anucleotide-sensing TLR which is activated bydouble-stranded RNA, a sign of viral infection.Acts via the adapter TRIF/TICAM1, leading toNF-kappa-B activation, IRF3 nucleartranslocation, cytokine secretion and theinflammatory response. Cellular Location: Endoplasmic reticulum membrane;Single-pass type I membrane protein.Endosome membrane. Early endosome. Tissue Location: Expressed at high level in placenta andpancreas. Also detected in CD11c+ immaturedendritic cells. Only expressed in dendriticcells and not in other leukocytes, includingmonocyte precursors. TLR3 is the TLR that isexpressed most strongly in the brain,especially in astrocytes, glia, and neurons.

牙冠抗体;免疫学;神经科学

The protein encoded by this gene is a member of the. Toll-like receptor (TLR) family which plays a fundamental role in. pathogen recognition and activation of innate immunity. TLRs are. highly conserved from Drosophila to humans and share structural and. functional similarities. They recognize pathogen-associated. molecular patterns (PAMPs) that are expressed on infectious agents,. and mediate the production of cytokines necessary for the. development of effective immunity. The various TLRs exhibit. different patterns of expression. This receptor is most abundantly. expressed in placenta and pancreas, and is restricted to the. dendritic subpopulation of the leukocytes. It recognizes dsRNA. associated with viral infection, and induces the activation of. NF-kappaB and the production of type I interferons. It may thus. play a role in host defense against viruses. Use of alternative. polyadenylation sites to generate different length transcripts has. been noted for this gene.

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :. Perez de Diego, R., et al. Immunity 33(3):400-411(2010). Zhou, Y., et al. Immunology 131(1):40-49(2010). Perrot, I., et al. J. Immunol. 185(4):2080-2088(2010). Paone, A., et al. Neoplasia 12(7):539-549(2010)

4507531

NP_003256.1

NM_003265.2

O15455

103829

Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098); Fatty Acid Degradation Pathway (7098)

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 4q35. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; cell surface; membrane; lysosomal membrane; integral to plasma membrane; cytoplasm; endosome membrane. Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; double-stranded RNA binding; receptor activity. Biological Process: negative regulation of osteoclast differentiation; I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of apoptosis; positive regulation of JNK cascade; positive regulation of interferon-alpha biosynthetic process; positive regulation of NF-kappaB import into nucleus; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; inflammatory response; defense response to virus; toll-like receptor 4 signaling pathway; MyD88-independent toll-like receptor signaling pathway; male gonad development; activation of NF-kappaB-inducing kinase; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; hyperosmotic response; positive regulation of chemokine biosynthetic process; detection of virus; defense response to bacterium; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; microglial cell activation during immune response; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process. Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

0.08毫升

165美元

0.4毫升

370