抗体

MMP14抗体(N末端)

MBS9201843

0.08毫升

165美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 流式细胞仪, 免疫组化-石蜡切片

抗体

MMP14抗体(N末端)

[MMP14]

[基质金属蛋白酶14;基质金属蛋白酶-14;基质金属蛋白酶-X1;膜类型基质金属蛋白酶1;MT-基质金属蛋白酶1;MTMMP1;膜类型基质金属蛋白酶;MT1-基质金属蛋白酶;MT1MMP;MMP14]

[matrix metalloproteinase-14 preproprotein; Matrix metalloproteinase-14; matrix metalloproteinase-14; matrix metallopeptidase 14 (membrane-inserted); MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP]

[MMP14]

[MMP14;MMP14;基质金属蛋白酶-14;基质金属蛋白酶-X1;MT-基质金属蛋白酶;MT1MMP;MTMMP1;WNCHRS;MT1-基质金属蛋白酶;MT-基质金属蛋白酶1;基质金属蛋白酶-14;MT-基质金属蛋白酶1;MTMMP1;MT1-基质金属蛋白酶;MT1MMP]

MMP14_HUMAN

多克隆

兔IgE

兔

Human, Mouse. Predicted: Bovine, Pig, Rat

[145-174]

582

This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14.

纯化兔多克隆抗体(多克隆抗体)

Purified polyclonal antibody supplied in PBSwith 0.09% (W/V) sodium azide. This antibodyis purified through a protein A column,followed by peptide affinity purification.

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

免疫组化-P, FC, 免疫印迹, E

免疫组化-P~~1:25。 FC~~1:10~50。 WB~~1:1000

免疫组化

Flow cytometric

免疫印迹

免疫印迹

MMP14 Antibody (R160) (Cat.# MBS9201843) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MMP14 antibody detected the MMP14 protein (arrow).

Antigen Source: HUMAN. Function: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2. Cellular Location: Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm. Tissue Location: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.

Crown Antibodies; Cancer; Cardiovascular; Cell Biology; Neuroscience; Signal Transduction

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.

Will, H., et al., Eur. J. Biochem. 231(3):602-608 (1995). Takino, T., et al., Gene 155(2):293-298 (1995). Okada, A., et al., Proc. Natl. Acad. Sci. U.S.A. 92(7):2730-2734 (1995). Sato, H., et al., Nature 370(6484):61-65 (1994).

4826834

NP_004986.1

NM_004995.3

P50281

Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323); Citrate Cycle (TCA Cycle) Pathway (4323)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

MMP14: Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Up-regulated by NANOS1. Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. Belongs to the peptidase M10A family. Protein type: Membrane protein, integral; Protease; Motility/polarity/chemotaxis; EC 3.4.24.80. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: extracellular matrix; focal adhesion; integral to plasma membrane; Golgi lumen; cytoplasm; melanosome; plasma membrane. Molecular Function: integrin binding; protein binding; protease activator activity; zinc ion binding; metalloendopeptidase activity; calcium ion binding; transcription factor activity. Biological Process: extracellular matrix organization and biogenesis; tissue remodeling; negative regulation of focal adhesion formation; male gonad development; embryonic cranial skeleton morphogenesis; proteolysis; positive regulation of cell growth; extracellular matrix disassembly; collagen catabolic process; branching morphogenesis of a tube; regulation of transcription, DNA-dependent; ovarian follicle development; response to estrogen stimulus; response to mechanical stimulus; endothelial cell proliferation; response to hypoxia; zymogen activation; angiogenesis; response to oxidative stress; astrocyte cell migration; endochondral ossification; positive regulation of cell migration; lung development. Disease: Winchester Syndrome

0.08毫升

165美元

0.4毫升

370