抗体

PDGFD抗体

MBS9203460

0.08毫升

165美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

PDGFD抗体

[PDGFD]

[Platelet-derived growth factor D; PDGF-D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B; Platelet-derived growth factor D; latent form; PDGFD latent form; Platelet-derived growth factor D; receptor-binding form; PDGFD receptor-binding form; PDGFD; IEGF; SCDGFB]

[platelet-derived growth factor D isoform 1; Platelet-derived growth factor D; platelet-derived growth factor D; platelet derived growth factor D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B]

[PDGFD]

[PDGFD; PDGFD; IEGF; SCDGFB; MSTP036; SCDGF-B; IEGF; SCDGFB; PDGF-D; SCDGF-B; PDGFD latent form; PDGFD receptor-binding form]

PDGFD_HUMAN

多克隆

兔IgE

兔

小鼠

364

This PDGFD antibody is generated from a rabbit immunized with a recombinant protein of human PDGFD.

纯化兔多克隆抗体(多克隆抗体)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

WB~~1:1000

免疫印迹(免疫印迹)

Calculated MW: 42848

Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). Cellular location: Secreted. Note=Released by platelets upon wounding. Tissue location: Tissue Location Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate,testis, small intestine, spleen and colon. Inthe kidney, expressed by the visceralepithelial cells of the glomeruli. A widespreadexpression is also seen in the medial smoothmuscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae inthe medullary area Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.

Cancer; Cardiovascular; Neuroscience; Signal Transduction

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).

Hamada T.,et al.Biochem. Biophys. Res. Commun. 280:733-737(2001). Bergsten E.,et al.Nat. Cell Biol. 3:512-516(2001). LaRochelle W.J.,et al.Nat. Cell Biol. 3:517-521(2001). Wistow G.,et al.Mol. Vis. 8:185-195(2002). Liu B.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.

13376808

NP_079484.1

NM_025208.4

Q9GZP0

Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310); Xylene Degradation Pathway (80310)

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide; Oncoprotein. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: Golgi membrane; endoplasmic reticulum lumen; extracellular region. Molecular Function: growth factor activity; platelet-derived growth factor receptor binding. Biological Process: multicellular organismal development; positive regulation of cell division; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation

0.08毫升

165美元

0.4毫升

370