抗体

ICOS抗体(C末端)

MBS9203882

0.08毫升

165美元

多克隆

兔

未共轭

免疫印迹, 酶联免疫吸附测定, 流式细胞仪, 流式细胞仪, 酶免疫法, 免疫组化-石蜡切片

抗体

ICOS抗体(C末端)

[ICOS]

[Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278; ICOS; AILIM]

[inducible T-cell costimulator; Inducible T-cell costimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278]

[ICOS]

[ICOS;ICOS;AILIM;CD278;CVID1;AILIM]

ICOS_HUMAN

多克隆

兔IgE

兔

人类

[156-185]

168

This ICOS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the C-terminal region of human ICOS.

纯化兔多克隆抗体(多克隆抗体)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA), 流式细胞仪(FC/流式细胞仪), 免疫组化石蜡(免疫组化-P)

免疫组化-P~~1:50~100。 WB~~1:1000。 FC~~1:10~50

免疫组化(免疫组化)

免疫印迹(免疫印迹)

流式细胞仪(FC/流式细胞仪)

Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Tissue Location: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

免疫学

ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

Okamoto, N., et al., Biochem. Biophys. Res. Commun. 310(3):691-702 (2003). Okamoto, T., et al., J. Rheumatol. 30(6):1157-1163 (2003). Riley, J.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(18):11790-11795 (2002). Haimila, K.E., et al., Immunogenetics 53(12):1028-1032 (2002). Witsch, E.J., et al., Eur. J. Immunol. 32(9):2680-2686 (2002).

15029518

NP_036224.1

NM_012092.3

Q9Y6W8

22625

Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851); Valine, Leucine And Isoleucine Degradation Pathway (29851)

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q33. Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; external side of plasma membrane. Biological Process: cell-cell adhesion; T cell tolerance induction; T cell costimulation; immune response. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 1

0.08毫升

165美元

0.4毫升

370