抗体

FGFR1 Antibody (Center)

MBS9204812

0.08毫升

165美元

多克隆

兔

未共轭

[RB50848]

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 流式细胞仪, 流式细胞仪, 酶免疫法

抗体

FGFR1 Antibody (Center)

[FGFR1]

[Fibroblast growth factor receptor 1; FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD331; FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR]

[fibroblast growth factor receptor 1 isoform 10; Fibroblast growth factor receptor 1; fibroblast growth factor receptor 1; fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD_antigen: CD331]

[FGFR1]

[FGFR1;FGFR1;CEK;FLG;HH2;OGD;FLT2;KAL2;BFGFR;CD331;FGFBR;FLT-2;HBGFR;N-SAM;FGFR-1;HRTFDS;bFGF-R-1;BFGFR;CEK;FGFBR;FLG;FLT2;HBGFR;FGFR-1;BFGFR;bFGF-R-1;FLT-2]

FGFR1_HUMAN

多克隆

兔IgE

[RB50848]

兔

Human, mouse (Predicted Reactivity: Chicken, Rat)

853

This FGFR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 291-324 amino acids from the Central region of human FGFR1.

纯化兔多克隆抗体(多克隆抗体)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

流式细胞仪(FC/流式细胞仪), 酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

FC~~1:25。 WB~~1:1000

流式细胞仪(FC/流式细胞仪)

免疫印迹(免疫印迹)

Cellular Location : Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus. Tissue Location: Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.

Crown Antibodies; Cancer; Cell Biology

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Itoh N.,et al.Biochem. Biophys. Res. Commun. 169:680-685(1990). Dionne C.A.,et al.EMBO J. 9:2685-2692(1990). Johnson D.E.,et al.Mol. Cell. Biol. 10:4728-4736(1990). Isacchi A.,et al.Nucleic Acids Res. 18:1906-1906(1990). Wennstroem S.,et al.Growth Factors 4:197-208(1991).

291327489

NP_001167534.1

NM_001174063.1

P11362

91868

D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260);D谷氨酰胺和D-谷氨酸代谢通路(2260)

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described. Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Oncoprotein; EC 2.7.10.1; TK group; FGFR family. Chromosomal Location of Human Ortholog: 8p11.23-p11.22. Cellular Component: integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane; extracellular region; cytosol; nucleus; receptor complex. Molecular Function: heparin binding; identical protein binding; protein binding; protein homodimerization activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding. Biological Process: paraxial mesoderm development; axon guidance; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; cell maturation; neuron migration; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; protein amino acid phosphorylation; positive regulation of MAP kinase activity; sensory perception of sound; positive regulation of MAPKKK cascade; ureteric bud development; induction of an organ; regulation of cell differentiation; midbrain development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; chondrocyte differentiation; angiogenesis; skeletal development; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; inner ear morphogenesis; cell migration; chordate embryonic development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; outer ear morphogenesis; MAPKKK cascade; positive regulation of cell cycle; positive regulation of phosphoinositide 3-kinase cascade; neuroblast division in the ventricular zone; mesenchymal cell differentiation; skeletal morphogenesis; insulin receptor signaling pathway; innate immune response; auditory receptor cell development; positive regulation of neuron differentiation; regulation of lateral mesodermal cell fate specification. Disease: Pfeiffer Syndrome; Hypogonadotropic Hypogonadism 2 With Or Without Anosmia; Jackson-weiss Syndrome; Trigonocephaly 1; Osteoglophonic Dysplasia

0.08毫升

165美元

0.4毫升

370