产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
ANO6抗体(N末端)
目录 :
MBS9208932
规格 :
0.08毫升
价格 :
165美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
图像
图像 1 :
ANO6 Antibody (N-term) western blot analysis in SW480 cell line lysates (35ug/lane).This demonstrates the ANO6 antibody detected the ANO6 protein (arrow).
产品信息
目录号 :
MBS9208932
产品类型 :
抗体
产品全称 :
ANO6抗体(N末端)
产品简称 :
[ANO6]
产品名称同义词 :
[Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, ANO6, TMEM16F]
其他名称 :
[anoctamin-6 isoform a; Anoctamin-6; anoctamin-6; anoctamin 6; Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F]
产品基因名称 :
[ANO6]
其他基因名称 :
[ANO6; ANO6; SCTS; BDPLT7; TMEM16F; TMEM16F; SCAN channel]
UniProt数据库进入名 :
ANO6_HUMAN
克隆性 :
多克隆
抗体亚型 :
兔IgE
宿主 :
兔
反应物种 :
人类
序列位置 :
[68-96]
序列长度 :
929
特异性 :
This ANO6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the N-terminal region of human ANO6.
纯度 :
肽亲和纯化兔多克隆抗体(多克隆抗体)
形式 :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
浓度 :
Vial Concentration: 0.5
储存稳定性 :
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
应用笔记 :
WB~~1:1000
image1头 :
免疫印迹(免疫印迹)
其它信息1 :
Antigen Type: Synthetic Peptide. Crown Antibody: Yes
其他信息2 :
Antigen Source: HUMAN. Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. Cellular Location: Cell membrane; Multi-pass membrane protein Note=Shows an intracellular localization according to PubMed:22075693. Tissue Location: Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer
产品种类 :
牙冠抗体
产品描述 :
May act as a calcium-activated chloride channel.
产品引用 :
Rose, J. Phd, et al. Mol. Med. (2010) In press :. Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009) :. Katoh, M., et al. Int. J. Oncol. 24(5):1345-1349(2004). Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :
NCBI GI登录号 :
218156299
NCBI登录号 :
NP_001020527.2
NCBI基因登录号 :
NM_001025356.2
UniProt数据库登录号 :
Q4KMQ2
NCBI分子量 :
106165
NCBI信号通路 :
Streptomycin Biosynthesis Pathway (196527); Streptomycin Biosynthesis Pathway (196527); Streptomycin Biosynthesis Pathway (196527)
NCBI总结 :
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt数据库总结 :
ANO6: May act as a calcium-activated chloride channel. It is essential for calcium-dependent exposure of phosphatidylserine on the surface of activated platelets, a process necessary to trigger the clotting system. Defects in ANO6 are the cause of Scott syndrome (SCTS). A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents. Belongs to the anoctamin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, ion channel; Transporter; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12q12. Cellular Component: cell surface; membrane; plasma membrane; intracellular. Molecular Function: phospholipid scramblase activity; protein homodimerization activity; intracellular calcium activated chloride channel activity; voltage-gated ion channel activity; voltage-gated chloride channel activity; calcium activated cation channel activity. Biological Process: activation of blood coagulation via clotting cascade; dendritic cell chemotaxis; chloride transport; phospholipid scrambling; blood coagulation; lipid transport; transmembrane transport; cation transport. Disease: Scott Syndrome
尺寸1 :
0.08毫升
价格1 :
165美元
尺寸2 :
0.4毫升
价格2 :
370
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。