产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
CALM1抗体(C末端)
目录 :
MBS9214524
规格 :
0.08毫升
价格 :
165美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪, 流式细胞仪, 酶免疫法
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS9214524 图像 1
Western blot analysis of CALM1 Antibody (C-term) in Hela cell line lysates (35ug/lane). CALM1 (arrow) was detected using the purified Pab.(2ug/ml)
图像 2 :
MyBioSource MBS9214524 图像 2
CALM1 Antibody (C-term) flow cytometry analysis of Hela cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
图像 3 :
MyBioSource MBS9214524 图像 3
CALM1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CALM1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
产品信息
目录号 :
MBS9214524
产品类型 :
抗体
产品全称 :
CALM1抗体(C末端)
产品简称 :
[CALM1]
产品名称同义词 :
[Calmodulin; CaM; CALM1; CALM; CAM; CAM1]
其他名称 :
[calmodulin isoform 2; Calmodulin; calmodulin; calmodulin 2 (phosphorylase kinase, delta)]
产品基因名称 :
[CALM1]
其他基因名称 :
[CALM2; CALM1; caM; PHKD; CAMII; LQT15; PHKD2; CALM; CAM; CAM1; CaM]
UniProt数据库进入名 :
CALM_HUMAN
克隆性 :
多克隆
抗体亚型 :
兔IgE
宿主 :
反应物种 :
Human (Predicted Reactivity: Bovine, C Elegans, Chicken, Zebrafish, Drosophila, Mouse, Rabbit, Rat, Xenopus)
序列位置 :
[107-132]
序列长度 :
149
特异性 :
This CALM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-132 amino acids from the C-terminal region of human CALM1.
纯度 :
肽亲和纯化兔多克隆抗体(多克隆抗体)
形式 :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
储存稳定性 :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA), 流式细胞仪(FC/流式细胞仪), 免疫组化(免疫组化), 免疫荧光(IF)
应用笔记 :
WB~~1:1000。 FC~~1:10~50。 免疫组化-P~~1:50~100。 IF~~1:10~50
image1头 :
免疫印迹(免疫印迹)
image2头 :
流式细胞仪(FC/流式细胞仪)
image3头 :
免疫组化(免疫组化)
image4头 :
免疫荧光(IF)
image4描述 :
Confocal immunofluorescent analysis of CALM1 Antibody (C-term) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
其他信息2 :
Cellular location: Cytoplasm, cytoskeleton, spindle. Cytoplasm,cytoskeleton, spindle pole. Note = Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. Function: Function Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
产品种类 :
Cancer; Cardiovascular; Cell Biology; Microbiology; Signal Transduction
产品描述 :
CALM1 is a member of the EF-hand calcium-binding protein family.Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
产品引用 :
Zhao,D., et.al., Zhonghua Yi Xue Za Zhi 88 (35), 2452-2456 (2008). Martins-de-Souza,D., et.al., J. Neural Transm. 116 (3), 275-289 (2009)
NCBI GI登录号 :
4502549
NCBI登录号 :
NP_001734.1
NCBI基因登录号 :
NM_001743.5
UniProt数据库登录号 :
P62158
NCBI分子量 :
16838
NCBI信号通路 :
花生四烯酸代谢通路(805);花生四烯酸代谢通路(805);花生四烯酸代谢通路(805);花生四烯酸代谢通路(805);花生四烯酸代谢通路(805);花生四烯酸代谢通路(805);花生四烯酸代谢通路(805);花生四烯酸代谢通路(805);花生四烯酸代谢通路(805);花生四烯酸代谢通路(805)
NCBI总结 :
This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
UniProt数据库总结 :
Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 14q32.11. Cellular Component: nucleoplasm; spindle pole; centrosome; sarcomere; growth cone; spindle microtubule; cytoplasm; plasma membrane; extracellular region; cytosol; nucleus; vesicle. Molecular Function: protein domain specific binding; nitric-oxide synthase regulator activity; titin binding; calcium ion binding; calcium-dependent protein binding; protein kinase binding; protein serine/threonine kinase activator activity; protein binding; N-terminal myristoylation domain binding; phospholipase binding; thioesterase binding; type 3 metabotropic glutamate receptor binding; phosphoinositide 3-kinase binding; nitric-oxide synthase binding; adenylate cyclase binding. Biological Process: positive regulation of phosphoprotein phosphatase activity; phototransduction, visible light; inositol phosphate metabolic process; nerve growth factor receptor signaling pathway; pathogenesis; signal transduction; nitric oxide metabolic process; positive regulation of protein amino acid dephosphorylation; synaptic transmission; platelet degranulation; substantia nigra development; muscle contraction; positive regulation of cyclic nucleotide metabolic process; response to corticosterone stimulus; epidermal growth factor receptor signaling pathway; mitochondrion organization and biogenesis; platelet activation; fibroblast growth factor receptor signaling pathway; glycogen catabolic process; regulation of heart rate; positive regulation of nitric-oxide synthase activity; organelle organization and biogenesis; response to amphetamine; adenylate cyclase activation; glucose metabolic process; regulation of cytokinesis; positive regulation of protein amino acid autophosphorylation; rhodopsin mediated signaling; G-protein coupled receptor protein signaling pathway; regulation of rhodopsin mediated signaling; phospholipase C activation; carbohydrate metabolic process; innate immune response; positive regulation of cyclic-nucleotide phosphodiesterase activity; detection of calcium ion; regulation of nitric-oxide synthase activity; vascular endothelial growth factor receptor signaling pathway; blood coagulation; response to calcium ion. Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
尺寸1 :
0.08毫升
价格1 :
165美元
尺寸2 :
0.4毫升
价格2 :
370
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。