ELISA/assay

Mouse Transient receptor potential Cation channel subfamily V member 4, TRPV4 ELISA Kit

MBS9325844

48-Strip-Wells

470美元

酶联免疫吸附试剂盒

Mouse Transient receptor potential Cation channel subfamily V member 4, TRPV4 ELISA Kit

[transient receptor potential cation channel, subfamily V, member 4]

[Mouse Transient receptor potential cation channel subfamily V member 4 (TRPV4) ELISA kit; OTRPC4; TRP12; VR-OAC; VRL-2; VRL2; VROAC; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; transient receptor potential channel 12; vanilloid rec; transient receptor potential cation channel; subfamily V; member 4]

[transient receptor potential cation channel subfamily V member 4; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel subfamily V member 4; trpv4 channel; osm-9-like TRP channel 4; vanilloid receptor-like channel 2; vanilloid receptor-like protein 2; transient receptor potential protein 12; osmosensitive transient receptor potential channel 4; vanilloid receptor-related osmotically-activated channel; transient receptor potential cation channel, subfamily V, member 4; Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmotically-activated channel; VR-OAC]

[TRPV4]

[Trpv4; Trpv4; Trp12; VRL-2; VROAC; OTRPC4; VR-OAC; 0610033B08Rik; Trp12; Vrl2; Vroac; TrpV4; OTRPC4; TRP12; VR-OAC]

TRPV4_MOUSE

小鼠

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Horse Serum, Plasma Or Tissue Homogenates Samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25ng/ml-8ng/ml. Sensitivity: 0.1ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of TRPV1 (hereafter termed "analyte") in undiluted original Horse serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

269784723

NP_071300.2

NM_022017.3

Q9EPK8

98,027 Da

TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation. Cellular Component: cortical actin cytoskeleton; focal adhesion; cell surface; cell; integral to membrane; cytosol; cilium; growth cone; adherens junction; membrane; cytoplasmic microtubule; lamellipodium; plasma membrane; cytoplasmic vesicle; cell junction; filopodium. Molecular Function: microtubule binding; calcium channel activity; ion channel activity; nucleotide binding; beta-tubulin binding; actin binding; protein kinase binding; actin filament binding; calmodulin binding; protein binding; protein kinase C binding; osmosensor activity; cation channel activity; SH2 domain binding; alpha-tubulin binding; ATP binding. Biological Process: intercellular junction assembly; hypotonic response; actin filament organization; response to osmotic stress; regulation of response to osmotic stress; cellular calcium ion homeostasis; osmosensory signaling pathway; vasopressin secretion; positive regulation of microtubule depolymerization; elevation of cytosolic calcium ion concentration; hyperosmotic salinity response; transport; calcium ion transport; actin cytoskeleton reorganization; ion transport; cortical microtubule organization and biogenesis; transmembrane transport; microtubule polymerization

48-Strip-Wells

470美元

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095