人类, 小鼠, 大鼠
图像 1 :
Western blot analysis of nNOS expression in INF treated RAW264.7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
[nitric oxide synthase, brain isoform 1; Nitric oxide synthase, brain; nitric oxide synthase, brain; nitric oxide synthase 1; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; N-NOS; nNOS; Peptidyl-cysteine S-nitrosylase NOS1; bNOS]
人类, 小鼠, 大鼠
Store at -20 °C. Stable for 12 months from date of receipt.
免疫印迹(免疫印迹), 免疫荧光(IF), 免疫细胞化学(免疫细胞化学)
WB 1:500-1:2000. IF/ICC 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.
Immunogen: A synthesized peptide derived from human nNOS
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
nNOS nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex.
NCBI GI登录号 :
Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Circadian Entrainment Pathway (698773)
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
nNOS: nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex. Four alternatively spliced isoforms have been described. Protein type: Amino Acid Metabolism - arginine and proline; EC 18.104.22.168; Oxidoreductase. Chromosomal Location of Human Ortholog: 12q24.22. Cellular Component: cytoplasm; cytoskeleton; cytosol; lipid raft; mitochondrion; perinuclear region of cytoplasm; photoreceptor inner segment; protein complex; sarcolemma; sarcoplasmic reticulum; synapse. Molecular Function: cadmium ion binding; FAD binding; FMN binding; heme binding; NADP binding; nitric-oxide synthase activity; protein binding; sodium channel regulator activity. Biological Process: arginine catabolic process; cell redox homeostasis; exogenous drug catabolic process; multicellular organismal response to stress; myoblast fusion; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of hydrolase activity; negative regulation of potassium ion transport; negative regulation of serotonin uptake; neurotransmitter biosynthetic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of guanylate cyclase activity; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; regulation of sodium ion transport; response to heat; response to hypoxia; striated muscle contraction. Disease: Pyloric Stenosis, Infantile Hypertrophic, 1
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308