抗体

水闸蛋白1(磷酸化Tyr210)抗体

MBS9384236

0.1毫升

440美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

水闸蛋白1(磷酸化Tyr210)抗体

[水闸蛋白1]

[CLDN1, 水闸蛋白1, 水闸蛋白1, ILVASC, SEMP1, CLD1]

[claudin-1; Claudin-1; claudin-1; claudin 1; Senescence-associated epithelial membrane protein]

[CLDN1;CLDN1;CLD1;SEMP1;ILVASC;CLD1;SEMP1]

多克隆

IgG

兔

人类, 小鼠, 大鼠

Claudin 1 (Phospho-Tyr210) Antibody detects endogenous levels of Claudin 1 only when phosphorylated at Tyr210

The Ab is from purifed rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns.

兔IgG在磷酸盐缓冲液, pH值7.4, 150mM氯化钠, 0.02% 叠氮化钠和50% 甘油

1.0毫克/毫升

Store at -20 °C.Stable for 12 months from date of receipt

免疫印迹(免疫印迹)

免疫印迹(免疫印迹)1:1000-3000。 免疫组化(免疫组化)1:50-1:200

免疫印迹

Immunogen: A synthesized peptide derived from human Claudin 1 (Phospho-Tyr210)

Subcellular Location: Cell junction,Tight junction,Cell membrane,Multi-pass membrane protein. Tissue Specificity: Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Subunit Structure: Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and PATJ (By similarity). Can form homo- and heteropolymers with other claudin family members.(Microbial infection) Interacts with hepatitis c virus E1 and E2 proteins.(Microbial infection) Interacts with dengue virus small envelope protein M. Similarity: Belongs to the claudin family. Note: For western blot, incubate membrane with diluted primary Abin 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking,overnight.

10863887

NP_066924.1

NM_021101.4

O95832

22kDa

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Nectin Adhesion Pathway (138054)

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]

Claudin-1: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Belongs to the claudin family. Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 3q28. Cellular Component: integral to membrane; integral to plasma membrane; tight junction. Molecular Function: identical protein binding; protein binding. Biological Process: calcium-independent cell-cell adhesion; intercellular junction assembly and maintenance; protein heterooligomerization; protein homooligomerization. Disease: Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis

0.1毫升

440美元

0.2毫升

715