产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
EDEM3抗体
目录 :
MBS9384638
规格 :
0.1毫升
价格 :
440美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹
更多信息或购买 :
MyBioSource 产品网页
图像
图像 1 :
MyBioSource MBS9384638 图像 1
Western blot analysis EDEM3 using HeLa whole cell lysates.
产品信息
目录号 :
MBS9384638
产品类型 :
抗体
产品全称 :
EDEM3抗体
产品简称 :
[EDEM3]
产品名称同义词 :
[alpha-1,2-mannosidase EDEM3; C1orf22; EDEM 3; edem3; EDEM3_HUMAN; ER degradation enhancer, mannosidase alpha like 3; ER degradation enhancing alpha mannosidase like 3; ER degradation enhancing alpha mannosidase like protein 3; ER degradation-enhancing alpha-mannosidase-like 3;]
其他名称 :
[ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 1; ER degradation-enhancing alpha-mannosidase-like protein 3; ER degradation-enhancing alpha-mannosidase-like protein 3; ER degradation enhancing alpha-mannosidase like protein 3; Alpha-1,2-mannosidase EDEM3]
产品基因名称 :
[EDEM3]
其他基因名称 :
[EDEM3;EDEM3;C1orf22;C1orf22]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠
序列长度 :
948
序列 :
MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTA
GAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELM
PLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVL
NKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLL
GGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFN
TTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLIL
EFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVT
INIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFL
ERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDAL
LAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFT
TDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTL
IENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFK
YLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSI
SKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIR
EPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATN
PEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAED
GLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVL
TAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAV
MGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSS
SDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
EYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQ
ISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASI
SPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDS
NPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
特异性 :
EDEM3抗体检测内生水平总数EDEM3
纯度 :
免疫原亲和纯化
浓度 :
1.0毫克/毫升
储存稳定性 :
Store at -20 degree C. Stable for 12 months from date of receipt.
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
Optimal dilutions/concentrations should be determined by the end user.
image1头 :
免疫印迹
其它信息1 :
Immunogen: A synthesized peptide derived from human EDEM3. Subcellular Location: Endoplasmic reticulum lumen. Similarity: Belongs to the glycosyl hydrolase 47 family.
其他信息2 :
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
产品描述 :
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).
NCBI GI登录号 :
985801665
NCBI登录号 :
NP_001306889.1
NCBI基因登录号 :
NM_001319960.1
UniProt数据库登录号 :
Q9BZQ6
NCBI分子量 :
105kDa
NCBI信号通路 :
Asparagine N-linked Glycosylation Pathway (1268714); Calnexin/calreticulin Cycle Pathway (1268723); ER Quality Control Compartment (ERQC) Pathway (1268724); Metabolism Of Proteins Pathway (1268677); N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway (1268722); Post-translational Protein Modification Pathway (1268701); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190)
NCBI总结 :
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
UniProt数据库总结 :
EDEM3: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity. Belongs to the glycosyl hydrolase 47 family. Protein type: EC 3.2.1.113; Hydrolase. Chromosomal Location of Human Ortholog: 1q25.3. Cellular Component: endoplasmic reticulum. Molecular Function: alpha-mannosidase activity; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Biological Process: ER-associated protein catabolic process; N-glycan processing; unfolded protein response
尺寸1 :
0.1毫升
价格1 :
440美元
尺寸2 :
0.2毫升
价格2 :
715
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。