抗体

TGFBR1(磷酸化Thr204)抗体

MBS9387846

0.1毫升

440美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

TGFBR1(磷酸化Thr204)抗体

[TGFBR1]

[TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, Activin receptor-like kinase 5, LDS1A, LDS2A, MSSE, SKR4, TGF beta receptor I, TGF-beta receptor type-1, TGF-beta type I receptor, TbetaR-I, TGFR-1, TGF-beta receptor type I]

[TGF-beta receptor type-1 isoform 2; TGF-beta receptor type-1; TGF-beta receptor type-1; transforming growth factor beta receptor 1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I]

[TGFBR1]

[TGFBR1; TGFBR1; AAT5; ALK5; ESS1; LDS1; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; tbetaR-I; ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I]

多克隆

IgG

兔

人类, 小鼠, 大鼠

426

TGFBR1 (Phospho-Thr204) Antibody detects endogenous levels of TGFBR1 only when phosphorylated at Thr204

免疫原亲和纯化

1.0毫克/毫升

Store at -20 °C.Stable for 12 months from date of receipt

免疫印迹(免疫印迹)

WB: 1:500~1:1000. Optimal dilutions/concentrations should be determined by the end user.

免疫印迹

Immunogen: A synthesized peptide derived from human TGFBR1 (Phospho-Thr204)

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

195963412

NP_001124388.1

NM_001130916.2

P36897

56 kDa.

ALK1 Signaling Events Pathway (137968); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518); Cytokine-cytokine Receptor Interaction Pathway (83051)

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

0.1毫升

440美元

0.2毫升

715