抗体

beta连环蛋白(磷酸化Thr41/Ser45)抗体

MBS9405161

0.05毫升

200美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

beta连环蛋白(磷酸化Thr41/Ser45)抗体

[beta连环蛋白]

[b-Catenin (Phospho-Thr41/Ser45) Antibody; CTNNB1; CATNB; CTNB1; CTNNB]

[catenin beta-1; Catenin beta-1; catenin beta-1; catenin (cadherin-associated protein), beta 1, 88kDa; Beta-catenin]

[CTNNB1;CTNNB1;CTNNB;MRD19;犰狳科;CTNNB]

CTNB1_HUMAN

多克隆

兔

人类, 小鼠, 大鼠

781

The antibody detects endogenous level of b-Catenin only when phosphorylated at threonine 41/serine 45.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0毫克/毫升

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

免疫印迹(免疫印迹)

Western blotting: 1:500~1:1000

免疫印迹(免疫印迹)

Immunogen Type: Peptide-KLH. Immunogen Description: Peptide sequence around phosphorylation site of threonine 41/serine 45 (A-T-T(p)-T-A-P-S(p)-L-S) derived from Human b-Catenin. Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antiboes were purified by affinity chromatography using epitope-specific phosphopeptide. Non-phosphospecific antibodes were removed by chromatography using non-phosphopeptide.

Modification: Phospho-Thr41/Ser45. Target Name: b-Catenin. Predicted MW: 92 kD

Phospho-specific Ab

Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

148233338

NP_001091679.1

NM_001098209.1

P35222

9,501 Da

Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Adherens Junctions Interactions Pathway (1270234); Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806); Apoptosis Pathway (1270262); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (1270290); Apoptotic Cleavage Of Cellular Proteins Pathway (1270288); Apoptotic Execution Phase Pathway (1270287); Arf6 Trafficking Events Pathway (137954)

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]

CTNNB1: a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Protein type: Nuclear receptor co-regulator; Actin-binding; Transcription factor; Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: centrosome; basolateral plasma membrane; fascia adherens; intercellular junction; beta-catenin destruction complex; cytosol; transcription factor complex; cell-cell adherens junction; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; spindle pole; tight junction; focal adhesion; cell cortex; catenin complex; Z disc; nucleoplasm; adherens junction; microvillus membrane; apical part of cell; plasma membrane; cell junction; nucleus. Molecular Function: protein C-terminus binding; transcription coactivator activity; transcription factor binding; protein phosphatase binding; ionotropic glutamate receptor binding; protein binding; signal transducer activity; enzyme binding; androgen receptor binding; cadherin binding; double-stranded DNA binding; protein complex binding; estrogen receptor binding; SMAD binding; nitric-oxide synthase binding; kinase binding; transcription factor activity; alpha-catenin binding; nuclear hormone receptor binding. Biological Process: regulation of myelination; regulation of centriole-centriole cohesion; positive regulation of apoptosis; protein heterooligomerization; regulation of fibroblast proliferation; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; cell maturation; T cell differentiation in the thymus; positive regulation of fibroblast growth factor receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; osteoclast differentiation; cell-cell adhesion; positive regulation of endothelial cell differentiation; positive regulation of mesenchymal cell proliferation; regulation of cell fate specification; embryonic foregut morphogenesis; synapse organization and biogenesis; male genitalia development; ectoderm development; cell adhesion; bone resorption; response to drug; positive regulation of neuroblast proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; regulation of smooth muscle cell proliferation; hair cell differentiation; negative regulation of protein sumoylation; genitalia morphogenesis; patterning of blood vessels; muscle cell differentiation; midgut development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; oocyte development; embryonic forelimb morphogenesis; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; apoptosis; cell-matrix adhesion; neuron migration; cell fate specification; dorsal/ventral axis specification; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of cell proliferation; central nervous system vasculogenesis; positive regulation of MAPKKK cascade; pancreas development; positive regulation of interferon type I production; fallopian tube development; proximal/distal pattern formation; layer formation in the cerebral cortex; cell structure disassembly during apoptosis; negative regulation of mitotic cell cycle, embryonic; Wnt receptor signaling pathway; hair follicle morphogenesis; thymus development; in utero embryonic development; embryonic axis specification; regulation of T cell proliferation; stem cell maintenance; neural plate development; synaptic vesicle transport; gastrulation with mouth forming second; liver development; regulation of angiogenesis; odontogenesis of dentine-containing teeth; negative regulation of oligodendrocyte differentiation; myoblast differentiation; Schwann cell proliferation; positive regulation of osteoblast differentiation; response to cadmium ion; ureteric bud branching; response to cytokine stimulus; androgen receptor signaling pathway; embryonic heart tube development; positive regulation of muscle cell differentiation; innate immune response; epithelial to mesenchymal transition; lens morphogenesis in camera-type eye; anterior/posterior axis specification. Disease: Pilomatrixoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Colorectal Cancer; Hepatocellular Carcinoma

0.05毫升

200美元

0.1毫升

255