抗体

AT1多克隆抗体

MBS9405524

0.05毫升

200美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法

抗体

AT1多克隆抗体

[AT1]

[AGTR1;AGTR1A;AGTR1B;AT2R1;AT2R1B;类型1血管紧张素Ⅱ受体;AT1AR;AT1BR;血管紧张素ii类型1受体;AT1]

[type-1 angiotensin II receptor isoform 1; Type-1 angiotensin II receptor; type-1 angiotensin II receptor; angiotensin II receptor, type 1; AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1]

[AT1]

[AGTR1;AGTR1;AT1;AG2S;AT1B;AT1R;AT1AR;AT1BR;AT2R1;HAT1R;AGTR1B;AGTR1A;AGTR1B;AT2R1;AT2R1B;AT1]

AGTR1_HUMAN

多克隆

兔

人类, 小鼠, 大鼠

359

AT1多克隆抗体检测内生水平AT1蛋白

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠

1毫克/毫升

Store at -20°C/1 year

免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 酶联免疫吸附测定(EIA)

Western Blot: 1:500 - 1:2000. Immunohistochemistry: 1:100 - 1:300. Immunofluorescence: 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

免疫印迹(免疫印迹)

Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the Internal region of human AT1.

Target Name: AT1. SDS-PAGE MW: 41kD

总数蛋白Ab

4501997

NP_000676.1

NM_000685.4

P30556

ACE Inhibitor Pathway (198763); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arf6 Signaling Events Pathway (138034); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574)

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 3q24. Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane. Molecular Function: protein binding; angiotensin type II receptor activity; protein heterodimerization activity; angiotensin type I receptor activity; bradykinin receptor binding. Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vasodilation; positive regulation of cellular protein metabolic process; renin-angiotensin regulation of aldosterone production; calcium-mediated signaling; regulation of systemic arterial blood pressure by renin-angiotensin; Rho protein signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; renin-angiotensin regulation of blood vessel size; regulation of vasoconstriction; regulation of inflammatory response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of cell growth; kidney development; positive regulation of phospholipase A2 activity; positive regulation of NAD(P)H oxidase activity; positive regulation of inflammatory response. Disease: Renal Tubular Dysgenesis; Hypertension, Essential

0.05毫升

200美元

0.1毫升

255