产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
GRM1抗体
目录 :
MBS9408789
规格 :
0.1毫升
价格 :
255美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS9408789 图像 1
Gel: 8%SDS-PAGE. Lysate: 60ug Hela cell. Primary antibody: 1/125 . Secondary antibody dilution: 1/8000. Exposure time: 1 minute
图像 2 :
MyBioSource MBS9408789 图像 2
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue at dilution 1/15.
产品信息
目录号 :
MBS9408789
产品类型 :
抗体
产品全称 :
GRM1抗体
产品简称 :
[GRM1]
产品名称同义词 :
[GRM1A;mGlu1;GPRC1A;MGLUR1;SCAR13;MGLUR1A]
其他名称 :
[metabotropic glutamate receptor 1 isoform alpha; Metabotropic glutamate receptor 1; metabotropic glutamate receptor 1; glutamate receptor, metabotropic 1]
产品基因名称 :
[GRM1]
其他基因名称 :
[GRM1;GRM1;MGLU1;GPRC1A;MGLUR1;SCAR13;PPP1R85;GPRC1A;MGLUR1;mGluR1]
UniProt数据库进入名 :
GRM1_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
1194
特异性 :
抗体检测内生水平总数GRM1蛋白
纯度 :
抗原亲和纯化
形式 :
兔IgG在pH7.3 PBS, 0.05% NaN3, 50% 甘油
储存稳定性 :
Store at -20 degree C
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
Western blotting: 1:500-1:2000. Immunohistochemistry: 1:15-1:50
image1头 :
试验数据
image2头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human glutamate receptor, metabotropic 1
其他信息2 :
Target Name: GRM1
产品种类 :
总数蛋白Ab
产品描述 :
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.
NCBI GI登录号 :
493798972
NCBI登录号 :
NP_000829
NCBI基因登录号 :
NM_001278064.1
UniProt数据库登录号 :
Q13255
NCBI分子量 :
132kd
NCBI信号通路 :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (1269573); Estrogen Signaling Pathway (799177); Estrogen Signaling Pathway (799197); FoxO Signaling Pathway (921162); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway (198839)
NCBI总结 :
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
UniProt数据库总结 :
mGluR1: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 3. Chromosomal Location of Human Ortholog: 6q24. Cellular Component: integral to plasma membrane; dendrite; postsynaptic density; plasma membrane; nucleus. Molecular Function: G-protein coupled receptor activity; protein binding; glutamate receptor activity. Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; activation of MAPK activity; metabotropic glutamate receptor signaling pathway; protein kinase C activation; locomotory behavior; regulation of sensory perception of pain; sensory perception of pain. Disease: Spinocerebellar Ataxia, Autosomal Recessive 13
尺寸1 :
0.1毫升
价格1 :
255美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。