抗体

Lipe Antibody

MBS9408847

0.1毫升

320美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

Lipe Antibody

[Lipe]

[激素敏感脂酶, HSL]

[lipase, hormone-sensitive; Hormone-sensitive lipase; hormone-sensitive lipase; lipase, hormone-sensitive]

[Lipe]

[LIPE;LIPE;HSL;LHS;AOMS4;FPLD6;HSL]

LIPS_HUMAN

多克隆

兔

人类, 小鼠, 大鼠

1076

Affinity chromatography purified via peptide column

用品在PBS含0.02% 叠氮化钠

1毫克/毫升

Can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

免疫印迹(免疫印迹)

免疫组化(免疫组化)

Immunogen Type: Peptide. Immunogen Description: Raised against a 14 amino acid peptide from near the carboxy terminus of human lipe.

Target Name: Lipe

总数蛋白Ab

Although initially described as an adipocyte-specific triacylglycerol lipase, lipe (also known as hormone-specific lipase or HSL) is expressed in multiple tissues and cell lines. It plays multiple roles in lipid metabolism, including hormone-stimulated lipolysis in adipose tissue and the hydrolysis of cholesterol esters. Lipe is expressed as a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesterol esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. Recently, it was observed that the lack of lipe in genetically obese leptin-null mice inhibited obesity and adipogenesis, suggesting that lipe plays a major role in adipocyte proliferation.

74418834

ABA03168

AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adipogenesis Pathway (198832); Fatty Acid Beta Oxidation Pathway (198865); Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway (1270009); Insulin Signaling Pathway (198845); Insulin Signaling Pathway (83090); Insulin Signaling Pathway (501); Lipid Digestion, Mobilization, And Transport Pathway (1270002)

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

HSL: hormone sensitive lipase is a lipolytic enzyme of the GDXG family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. Protein type: EC 3.1.1.79; Lipase. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: lipid particle; caveola; cytosol. Molecular Function: triacylglycerol lipase activity; hormone-sensitive lipase activity; protein binding; protein kinase binding. Biological Process: cholesterol metabolic process; triacylglycerol catabolic process; diacylglycerol catabolic process; protein amino acid phosphorylation; lipid catabolic process; long-chain fatty acid catabolic process. Disease: Abdominal Obesity-metabolic Syndrome 4

0.1毫升

320美元