产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MMP2抗体
目录 :
MBS9410513
规格 :
0.1毫升
价格 :
255美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS9410513 图像 1
Western blot analysis of extracts of various cell lines, using MMP2 antibody.
产品信息
目录号 :
MBS9410513
产品类型 :
抗体
产品全称 :
MMP2抗体
产品简称 :
[MMP2]
产品名称同义词 :
[CLG4;MONA;CLG4A;TBE-1;基质金属蛋白酶-II]
其他名称 :
[72 kDa type IV collagenase isoform 2; 72 kDa type IV collagenase; 72 kDa type IV collagenase; matrix metallopeptidase 2; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2]
产品基因名称 :
[MMP2]
其他基因名称 :
[MMP2;MMP2;CLG4;MONA;CLG4A;基质金属蛋白酶-2;TBE-1;基质金属蛋白酶-II;CLG4A;基质金属蛋白酶-2]
UniProt数据库进入名 :
MMP2_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
610
特异性 :
抗体检测内生水平总数MMP2蛋白
纯度 :
Antibodies were purified by affinity purification using immunogen.
形式 :
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度 :
1.0毫克/毫升
储存稳定性 :
Store at -20 degree C
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
Western blotting: 1:500 - 1:2000. Immunohistochemistry: 1:50 - 1:200
image1头 :
免疫印迹(免疫印迹)
其它信息1 :
Immunogen Type: Recombinant Protein. Immunogen Description: Recombinant protein of human MMP2.
其他信息2 :
Target Name: MMP2
产品种类 :
总数蛋白Ab
产品描述 :
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
NCBI GI登录号 :
189217853
NCBI登录号 :
NP_001121363.1
NCBI基因登录号 :
NM_001127891.2
UniProt数据库登录号 :
P08253
NCBI分子量 :
74KD
NCBI信号通路 :
AGE/RAGE Pathway (698754); ATF-2 Transcription Factor Network Pathway (138006); Activation Of Matrix Metalloproteinases Pathway (1270258); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Axon Guidance Pathway (1270303); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Collagen Degradation Pathway (1270259); Degradation Of The Extracellular Matrix Pathway (1270257); Developmental Biology Pathway (1270302)
NCBI总结 :
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
UniProt数据库总结 :
MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Interacts (via the C-terminal hemopexin-like domains- containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B. Aspirin appears to inhibit expression. Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. Inhibited by histatin-3 1/24 (histatin-5). Belongs to the peptidase M10A family. Protein type: Motility/polarity/chemotaxis; Apoptosis; EC 3.4.24.24; Cell development/differentiation; Protease; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 16q12.2. Cellular Component: proteinaceous extracellular matrix; extracellular space; sarcomere; mitochondrion; extracellular region; plasma membrane; nucleus. Molecular Function: protein binding; zinc ion binding; serine-type endopeptidase activity; metalloendopeptidase activity. Biological Process: axon guidance; extracellular matrix organization and biogenesis; intramembranous ossification; proteolysis; blood vessel maturation; collagen catabolic process; extracellular matrix disassembly; cellular protein metabolic process; positive regulation of innate immune response; ephrin receptor signaling pathway; response to hypoxia; angiogenesis; embryo implantation. Disease: Multicentric Osteolysis, Nodulosis, And Arthropathy
尺寸1 :
0.1毫升
价格1 :
255美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。