产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Cox-2 Polyclonal Antibody
目录 :
MBS9410607
规格 :
0.05毫升
价格 :
200美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS9410607 图像 1
Western Blot analysis of A549 cells using Cox-2 Polyclonal Antibody
图像 2 :
MyBioSource MBS9410607 图像 2
Western Blot analysis of VEC cells using Cox-2 Polyclonal Antibody
产品信息
目录号 :
MBS9410607
产品类型 :
抗体
产品全称 :
Cox-2 Polyclonal Antibody
产品简称 :
[Cox-2]
产品名称同义词 :
[PTGS2; COX2; Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2]
其他名称 :
[prostaglandin G/H synthase 2; Prostaglandin G/H synthase 2; prostaglandin G/H synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2]
产品基因名称 :
[Cox-2]
其他基因名称 :
[PTGS2; PTGS2; COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS; COX2; COX-2; PGH synthase 2; PGHS-2]
UniProt数据库进入名 :
PGH2_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类
序列长度 :
604
特异性 :
Cox-2 Polyclonal Antibody detects endogenous levels of Cox-2 protein.
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
形式 :
液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20°C/1 year
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 酶联免疫吸附测定(EIA)
应用笔记 :
Western Blot: 1:500 - 1:2000. Immunohistochemistry: 1:100 - 1:300. Immunofluorescence: 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫印迹(免疫印迹)
其它信息1 :
Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the C-terminal region of human Cox-2.
其他信息2 :
Target Name: Cox-2. SDS-PAGE MW: 80kD
产品种类 :
总数蛋白Ab
NCBI GI登录号 :
4506265
NCBI登录号 :
NP_000954.1
NCBI基因登录号 :
NM_000963.3
UniProt数据库登录号 :
P35354
NCBI信号通路 :
Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (1270087); Arachidonic Acid Metabolism Pathway (366); C-MYB Transcription Factor Network Pathway (138073); C20 Prostanoid Biosynthesis Pathway (545299); C20 Prostanoid Biosynthesis Pathway (908107); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237)
NCBI总结 :
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
UniProt数据库总结 :
COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family. Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.99.1. Chromosomal Location of Human Ortholog: 1q25.2-q25.3. Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; cytoplasm; caveola; nucleus. Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; protein homodimerization activity; enzyme binding; arachidonate 15-lipoxygenase activity; metal ion binding; heme binding; lipid binding. Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; response to lithium ion; response to glucocorticoid stimulus; response to lipopolysaccharide; positive regulation of NF-kappaB import into nucleus; decidualization; prostaglandin biosynthetic process; sensory perception of pain; negative regulation of synaptic transmission, dopaminergic; positive regulation of synaptic transmission, glutamatergic; response to estradiol stimulus; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; response to vitamin D; lipoxygenase pathway; nicotinamide metabolic process; regulation of blood pressure; negative regulation of smooth muscle contraction; arachidonic acid metabolic process; angiogenesis; positive regulation of smooth muscle contraction; inflammatory response; water-soluble vitamin metabolic process; response to fructose stimulus; positive regulation of prostaglandin biosynthetic process; response to drug; negative regulation of calcium ion transport; vitamin metabolic process; cyclooxygenase pathway; positive regulation of synaptic plasticity; learning; memory; hair cycle; prostaglandin metabolic process; response to manganese ion; ovulation; NAD metabolic process; regulation of inflammatory response; brown fat cell differentiation; positive regulation of vasoconstriction; positive regulation of fever; response to oxidative stress; cell motility; embryo implantation
尺寸1 :
0.05毫升
价格1 :
200美元
尺寸2 :
0.1毫升
价格2 :
255
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。