产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
重组人类B淋巴细胞 抗原CD20
目录 :
MBS950769
规格 :
INQUIRE
价格 :
INQUIRE
更多信息或购买 :
产品信息
目录号 :
MBS950769
产品类型 :
重组蛋白
产品全称 :
重组人类B淋巴细胞 抗原CD20
产品简称 :
B淋巴细胞 抗原CD20
产品名称同义词 :
B-lymphocyte surface antigen B1Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20
其他名称 :
B-lymphocyte antigen CD20; B-lymphocyte antigen CD20; B-lymphocyte antigen CD20; membrane spanning 4-domains A1; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
产品基因名称 :
跨膜结构域4超家族成员1
其他基因名称 :
跨膜结构域4超家族成员1;跨膜结构域4超家族成员1;B1;S7;Bp35;CD20;CVID5;MS4A2;LEU-16;CD20
UniProt数据库进入名 :
CD20_HUMAN
宿主 :
E Coli or Yeast or Baculovirus or Mammalian Cell
序列位置 :
141-297
序列长度 :
130
序列 :
IKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPS
TQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKR
TCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPK
NEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSS
P
纯度 :
Greater than 90% as determined by SDS-PAGE.
形式 :
Liquid containing glycerol; lyophilization may be available upon request.
储存稳定性 :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
产品种类 :
免疫学
产品描述 :
This protein may be involved in the regulation of B-cell activation and proliferation.
产品引用 :
Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35) , a type III integral membrane protein.Stamenkovic I., Seed B.J. Exp. Med. 167:1975-1980(1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes.Tedder T.F., Streuli M., Schlossman S.F., Saito H.Proc. Natl. Acad. Sci. U.S.A. 85:208-212(1988) Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains.Einfeld D.A., Brown J.P., Valentine M.A., Clark E.A., Ledbetter J.A.EMBO J. 7:711-717(1988) Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1) .Tedder T.F., Klejman G., Schlossman S.F., Saito H.J. Immunol. 142:2560-2568(1989) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006)
NCBI GI登录号 :
23110987
NCBI登录号 :
NP_068769.2
NCBI基因登录号 :
NM_021950.3
UniProt数据库登录号 :
P11836
NCBI分子量 :
20kD
NCBI信号通路 :
Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)
NCBI总结 :
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family. Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 11q12. Cellular Component: external side of plasma membrane; extracellular space; integral to plasma membrane. Molecular Function: epidermal growth factor receptor binding; protein binding. Biological Process: B cell proliferation; humoral immune response. Disease: Immunodeficiency, Common Variable, 5
尺寸1 :
INQUIRE
价格1 :
INQUIRE
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。