蛋白

重组人类C-趋化因子C受体类型2(趋化因子受体2)

MBS951130

1毫克(大肠杆菌)

1090美元

重组蛋白

重组人类C-趋化因子C受体类型2(趋化因子受体2)

C-趋化因子C受体类型2(趋化因子受体2)

重组C-趋化因子C受体类型2(趋化因子受体2);C-趋化因子C受体类型2;C-C CKR-2;CC-CKR;CCR-2;趋化因子受体2;单核细胞趋化蛋白1受体;MCP-1 CD_antigen=CD192

C-C chemokine receptor type 2 isoform A; C-C chemokine receptor type 2; C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemotactic protein 1 receptor; monocyte chemoattractant protein 1 receptor; chemokine (C-C motif) receptor 2; Monocyte chemoattractant protein 1 receptor

趋化因子受体2;CMKBR2

趋化因子受体2;趋化因子受体2;CKR2;CCR-2;CCR2A;CCR2B;CD192;CKR2A;CKR2B;CMKBR2;MCP-1;CC-CKR;CMKBR2;C-C CKR-2;CC-CKR;CCR-2;趋化因子受体2;MCP-1

CCR2_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

310-374

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Homo sapiens (Human)

183979980

NP_001116513.2

NM_001123041.2

P41597

41,915 Da

Beta Defensins Pathway (530759); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defensins Pathway (530757); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: cell soma; perinuclear region of cytoplasm; integral to plasma membrane; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol. Molecular Function: protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity. Biological Process: positive regulation of T-helper 1 type immune response; viral reproduction; chemotaxis; elevation of cytosolic calcium ion concentration; response to wounding; dendritic cell chemotaxis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; cellular defense response; innate immune response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; negative regulation of eosinophil degranulation; positive regulation of T cell activation; positive regulation of inflammatory response

1毫克(大肠杆菌)

1090美元

1毫克(酵母)

1540