产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
FZD2抗体
目录 :
MBS9601455
规格 :
0.1毫升
价格 :
240美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 酶免疫法
更多信息或购买 :
MyBioSource 产品网页
图像
图像 1 :
MyBioSource MBS9601455 图像 1
MBS9601455 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
图像 2 :
MyBioSource MBS9601455 图像 2
Western blot analysis of FZD2 expression in HeLa cells
产品信息
目录号 :
MBS9601455
产品类型 :
抗体
产品全称 :
FZD2抗体
产品简称 :
[FZD2]
产品名称同义词 :
[Frizzled homolog 2; Frizzled-2; Frizzled2; Fz 2; Fz-2; Fz2; FZD 2; FZD2; FZD2_HUMAN; FzE 2; FzE2; hFz 2; hFz2; Mfz10]
其他名称 :
[frizzled-2; Frizzled-2; frizzled-2; frizzled class receptor 2; FzE2]
产品基因名称 :
[FZD2]
其他基因名称 :
[FZD2; FZD2; Fz2; fz-2; fzE2; hFz2; Fz-2; hFz2]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
565
特异性 :
FZD2抗体检测内生水平总数FZD2
纯度 :
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
形式 :
兔IgG在磷酸盐缓冲液, pH值7.4, 150mM氯化钠, 0.02% 叠氮化钠和50% 甘油
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20 degree C. Stable for 12 months from date of receipt.
检测过的应用 :
免疫印迹(免疫印迹), 免疫荧光(IF), 免疫细胞化学(免疫细胞化学), 酶联免疫吸附测定(EIA)
应用笔记 :
WB: 1:500-1:2000。 IF: 1:100-1:500
image1头 :
免疫荧光(IF)
image2头 :
免疫印迹(免疫印迹)
其它信息1 :
Immunogen: A synthesized peptide derived from human FZD2, corresponding to a region within the internal amino acids.
其他信息2 :
Similarity: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.The FZ domain is involved in binding with Wnt ligands. Belongs to the G-protein coupled receptor Fz/Smo family.
NCBI GI登录号 :
4503827
NCBI登录号 :
NP_001457.1
NCBI基因登录号 :
NM_001466.3
UniProt数据库登录号 :
Q14332
NCBI分子量 :
63 kDa
NCBI信号通路 :
Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Class B/2 (Secretin Family Receptors) Pathway (106378); GPCR Ligand Binding Pathway (161020); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Melanogenesis Pathway (83092); Melanogenesis Pathway (504)
NCBI总结 :
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]
UniProt数据库总结 :
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
尺寸1 :
0.1毫升
价格1 :
240美元
尺寸2 :
0.2毫升
价格2 :
280
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。