蛋白

Recombinant Human Microtubule-associated protein tau

MBS960371

0.05毫克(大肠杆菌)

180美元

重组蛋白

Recombinant Human Microtubule-associated protein tau

Microtubule-associated protein tau

Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

Microtubule-associated protein tau; microtubule-associated protein tau; microtubule associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

MAPT

MAPT; MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103; MAPTL; MTBT1; TAU; PHF-tau

TAU_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

2-383; Provide the full length of Isoform Tau-D (identifier: P10636-6).

383

AEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTD
AGLKAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGS
DDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTP
PAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSL
PTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLK
NVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGS
KDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKP
GGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKI
ETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSN
VSSTGSIDMVDSPQLATLADEVSASLAKQGL

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

神经科学

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease identification as the microtubule-associated protein tau.Goedert M., Wischik C., Crowther R., Walker J., Klug A.Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988)

NP_001116538.2

P10636

44kD

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Apoptosis Pathway (1270262); Apoptotic Cleavage Of Cellular Proteins Pathway (1270288); Apoptotic Execution Phase Pathway (1270287); BDNF Signaling Pathway (712093); Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway (1270289); IL-2 Signaling Pathway (198885); IL-6 Signaling Pathway (198864)

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21.1. Cellular Component: axon; axoneme; cytosol; dendrite; growth cone; microtubule; microtubule associated complex; plasma membrane; postsynaptic density; tubulin complex. Molecular Function: apolipoprotein binding; enzyme binding; microtubule binding; protein binding; protein kinase binding; protein phosphatase 2A binding; SH3 domain binding; structural constituent of cytoskeleton. Biological Process: adult walking behavior; apoptosis; axon cargo transport; axon extension; brain development; cell structure disassembly during apoptosis; female pregnancy; generation of neurons; induction of apoptosis by oxidative stress; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule; negative regulation of intracellular transport; neurite development; neuron migration; positive regulation of axon extension; positive regulation of microtubule polymerization; programmed cell death; regulation of autophagy; regulation of microtubule polymerization; response to nutrient; response to organic substance. Disease: Frontotemporal Dementia; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Parkinson Disease, Late-onset; Parkinson-dementia Syndrome; Pick Disease Of Brain; Supranuclear Palsy, Progressive, 1

0.05毫克(大肠杆菌)

180美元

0.2毫克(大肠杆菌)

490

0.5毫克(大肠杆菌)

715

0.05毫克(杆状病毒)

950

1毫克(大肠杆菌)

1170