产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
FGF23抗体
目录 :
MBS9605052
规格 :
0.1毫升
价格 :
240美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 酶免疫法
更多信息或购买 :
MyBioSource 产品网页
图像
图像 1 :
MyBioSource MBS9605052 图像 1
Western blot analysis of extracts from HepG2, using FGF23 Antibody. Lane 1 was treated with the blocking peptide.
图像 2 :
MyBioSource MBS9605052 图像 2
Western blot analysis of FGF23 Antibody expression in mouse lung tissue lysates.The lane on the right is treated with the antigen-specific peptide.
图像 3 :
MyBioSource MBS9605052 图像 3
MBS9605052 staining U87 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
产品信息
目录号 :
MBS9605052
产品类型 :
抗体
产品全称 :
FGF23抗体
产品简称 :
[FGF23]
产品名称同义词 :
[ADHR; FGF-23; Fgf23; FGF23_HUMAN; FGFN; Fibroblast growth factor 23; Fibroblast growth factor 23 C-terminal peptide; Fibroblast growth factor 23 precursor; HPDR2; HYPF; Phosphatonin; PHPTC; Tumor derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor]
其他名称 :
[fibroblast growth factor 23; Fibroblast growth factor 23; fibroblast growth factor 23; fibroblast growth factor 23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor]
产品基因名称 :
[FGF23]
其他基因名称 :
[FGF23;FGF23;ADHR;FGFN;HYPF;HFTC2;HPDR2;PHPTC;HYPF;FGF-23]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
251
特异性 :
FGF23抗体检测内生水平总数FGF23
纯度 :
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
形式 :
液体。 磷酸盐缓冲液, pH值7.4, 150mM氯化钠, 0.02% 叠氮化钠和50% 甘油
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20 degree C. Stable for 12 months from date of receipt.
检测过的应用 :
免疫印迹(免疫印迹), 免疫荧光(IF), 免疫细胞化学(免疫细胞化学), 酶联免疫吸附测定(EIA)
应用笔记 :
IF/ICC: 1:100-1:500。 WB: 1:500-1000
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫印迹(免疫印迹)
image3头 :
免疫荧光(IF)
其它信息1 :
Immunogen: A synthesized peptide. Subcellular Location: Secreted. Secretion is dependent on O-glycosylation. Tissue Specificity: Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). Predicted Cross Reactivity : Horse, Dog . Similarity: Belongs to the heparin-binding growth factors family.
其他信息2 :
Conjugation: Unconjugated
产品描述 :
Function: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Subunit Structure: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity). Post-translational Modifications: Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases. O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2, 6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23. Similarity: Belongs to the heparin-binding growth factors family.
NCBI GI登录号 :
10190674
NCBI登录号 :
NP_065689.1
NCBI基因登录号 :
NM_020638.2
UniProt数据库登录号 :
Q9GZV9
NCBI分子量 :
27 kD
NCBI信号通路 :
Activated Point Mutants Of FGFR2 Pathway (645281); Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signal Transduction Pathway (106385); Downstream Signaling Of Activated FGFR Pathway (160957); FGF Signaling Pathway (137989)
NCBI总结 :
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
UniProt数据库总结 :
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (). Acts directly on the parathyroid to decrease PTH secretion (). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
尺寸1 :
0.1毫升
价格1 :
240美元
尺寸2 :
0.2毫升
价格2 :
280
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。