蛋白

重组人类硫氧还蛋白(TXN)

MBS960600

0.5毫克(大肠杆菌)

835美元

重组蛋白

重组人类硫氧还蛋白(TXN)

硫氧还蛋白(TXN)

Thioredoxin; Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP

thioredoxin isoform 2; Thioredoxin; thioredoxin; ADF; SASP; TXN delta 3; ATL-derived factor; thioredoxin delta 3; surface-associated sulphydryl protein; thioredoxin; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP

TXN

TXN;TRDX;TRX;TRX1

TXN; TXN; TRX; TRDX; TRX1; TRDX; TRX; TRX1; Trx; ADF; SASP

THIO_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

2-105

104

VKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

349732256

NP_001231867.1

NM_001244938.1

P10599

9,452 Da

Folic Acid Network Pathway (219799); Folic Acid Network Pathway (198383); Immune System Pathway (106386); Inflammasomes Pathway (366166); Innate Immune System Pathway (106387); Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (366164); Selenium Pathway (219762); Selenium Pathway (198359)

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

TXN: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family. Protein type: Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 9q31. Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; protein disulfide oxidoreductase activity; peptide disulfide oxidoreductase activity. Biological Process: negative regulation of protein export from nucleus; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; activation of protein kinase B; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of peptidyl-serine phosphorylation; glycerol ether metabolic process; positive regulation of protein kinase B signaling cascade; cell proliferation; response to reactive oxygen species; response to radiation; cell-cell signaling; cell redox homeostasis; regulation of protein import into nucleus, translocation; innate immune response; cell motility; positive regulation of DNA binding

0.5毫克(大肠杆菌)

835美元

0.05毫克(杆状病毒)

835

0.5毫克(酵母)

1060

0.05 mg (Mammalian-Cell)

1060

1毫克(大肠杆菌)

1200