蛋白

重组人类n-myc原癌基因蛋白

MBS962181

0.05毫克(大肠杆菌)

190美元

重组蛋白

重组人类n-myc原癌基因蛋白

n-myc原癌基因

Class E basic helix-loop-helix protein 37; bHLHe37

N-myc proto-oncogene protein isoform 1; N-myc proto-oncogene protein; N-myc proto-oncogene protein; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; Class E basic helix-loop-helix protein 37; bHLHe37

MYCN

MYCN;MYCN;NMYC;ODED;MODED;N-myc;bHLHe37;BHLHE37;NMYC;bHLHe37

MYCN_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-464

464

MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGG
PDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWV
TEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMW
SGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAAS
PAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPF
PVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGV
APPRPGGRQTSGGDHKALSTS

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Cancer

May function as a transcription factor.

Nucleotide sequence of the human N-myc gene.Stanton L.W., Schwab M., Bishop J.M.Proc. Natl. Acad. Sci. U.S.A. 83:1772-1776(1986)

648216288

NP_001280157.1

NM_001293228.1

P04198

51.56kD

Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

N-Myc: a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors. Protein type: DNA-binding; Transcription factor; Oncoprotein. Chromosomal Location of Human Ortholog: 2p24.3. Cellular Component: chromatin; nucleus. Molecular Function: DNA binding; protein binding; protein dimerization activity; transcription factor activity. Biological Process: positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent. Disease: Feingold Syndrome 1; Tracheoesophageal Fistula With Or Without Esophageal Atresia

0.05毫克(大肠杆菌)

190美元

0.2毫克(大肠杆菌)

460

0.5毫克(大肠杆菌)

750

1毫克(大肠杆菌)

1180

0.05毫克(杆状病毒)

1245