蛋白

Recombinant Mouse Microtubule-associated protein tau

MBS964528

0.05毫克(大肠杆菌)

180美元

重组蛋白

Recombinant Mouse Microtubule-associated protein tau

Microtubule-associated protein tau

Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

microtubule-associated protein tau isoform a; Microtubule-associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

Mapt

Mapt; Mapt; Tau; Mtapt; AI413597; AW045860; Mtapt; Tau; PHF-tau

TAU_MOUSE

E Coli or Yeast or Baculovirus or Mammalian Cell

2-733, 全长

733

ADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKESPPQPP
ADDGAEEPGSETSDAKSTPTAEDVTAPLVDERAPDKQAA
AQPHTEIPEGITAEEAGIGDTPNQEDQAAGHVTQGRREG
QAPDLGTSDWTRQQVSSMSGAPLLPQGLREATCQPSGTR
PEDIEKSHPASELLRRGPPQKEGWGQDRLGSEEEVDEDL
TVDESSQDSPPSQASLTPGRAAPQAGSGSVCGETASVPG
LPTEGSVPLPADFFSKVSAETQASQPEGPGTGPMEEGHE
AAPEFTFHVEIKASTPKEQDLEGATVVGVPGEEQKAQTQ
GPSVGKGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKAR
VASKDRTGNDEKKAKTSTPSCAKAPSHRPCLSPTRPTLG
SSDPLIKPSSPAVSPEPATSPKHVSSVTPRNGSPGTKQM
KLKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTP
SPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLP
TPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKN
VRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSK
DNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPG
GGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIE
THKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNV
SSTGSIDMVDSPQLATLADEVSASLAKQGL

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Species: Mus musculus (Mouse)

神经科学

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Expression of three- and four-repeat tau isoforms in mouse liver." Kenner L., el-Shabrawi Y., Hutter H., Forstner M., Zatloukal K., Hoefler G., Preisegger K.-H., Kurzbauer R., Denk H. Hepatology 20:1086-1089(1994)

84370347

NP_001033698.1

NM_001038609.2

P10637

78.11kD

Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Apoptosis Pathway (1323524); Apoptotic Cleavage Of Cellular Proteins Pathway (1323549); Apoptotic Execution Phase Pathway (1323548); Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway (1323550); IL-6 Signaling Pathway (198302); MAPK Signaling Pathway (198294); MAPK Signaling Pathway (83245); MAPK Signaling Pathway (456)

Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization. Protein type: Cytoskeletal. Cellular Component: axon; axoneme; cell projection; cytoplasm; cytoskeleton; dendrite; growth cone; membrane; microtubule; microtubule associated complex; microtubule cytoskeleton; neuron projection; nucleus; plasma membrane; postsynaptic density; tubulin complex. Molecular Function: apolipoprotein binding; enzyme binding; Hsp90 protein binding; microtubule binding; protein binding; protein complex binding; protein domain specific binding; protein kinase binding; protein phosphatase 2A binding; SH3 domain binding; tubulin binding. Biological Process: adult walking behavior; apoptosis; axon cargo transport; axon extension; axonogenesis; induction of apoptosis by oxidative stress; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule; negative regulation of intracellular transport; neuron migration; positive regulation of axon extension; positive regulation of microtubule polymerization; regulation of autophagy; response to nutrient; response to organic substance

0.05毫克(大肠杆菌)

180美元

0.05毫克(酵母)

260

0.2毫克(大肠杆菌)

490

0.2毫克(酵母)

600

0.5毫克(大肠杆菌)

715